Radiotherapy in Managing Brain Metastases

Yoshiya Yamada MD FRCPC is Attending Radiation Oncologist in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center. Eric Chang MD, FASTRO is Professor and Chair in the Department of Radiation Oncology at Keck School of Medicine, University of Southern California. Dr. Chang is also volume editor of the forthcoming Adult CNS Radiation Oncology. John Fiveash MD is Professor and Vice Chair of the Department of Radiation Oncology at the University of Alabama Birmingham. Jonathan Knisely MD is in the Department of Radiation Oncology at Weill Cornell Medical Center.

Introduction.- SECTION I: Clinical Overview.- Brain Metastases Introduction.- Radiobiology of Radiation Therapy for the Brain.- Supportive Medical Management of Brain Metastases Patients.- Neuorimaging of Brain Metastases.- Integrative Surgery and Radiosurgery.- Integrating Systemic Therapy into Management.- Indications for SRS-Multiple Mets.- Rationale for Hypofractionation.- Target Delineation for Radiosurgery.- Indications for WBRT.- Particle Therapy for the Treatment of Brain Metastases.- Special Topics.- Salvage, Reirradiation, and Retreatment.- SECTION II: Technical Treatment Planning and Delivery.- General Techniques for Radiosurgery.- Single Isocenter Techniques for Multiple Targets.- Dose Tolerances for Normal Structures.- Metrics for Radiosurgery Plan.- Image Guidance for Frameless Radiosurgery.- Safety Procedures and Checklists for Radiosurgery.- Quality Assurance for Small Fields.- Techniques of WBRT.