ERS Handbook of Respiratory Medicine

1 – Structure and function of the respiratory system
Anatomy of the respiratory system 1
Cytology of the lung 7
Immunology and defence mechanisms 20
2 – Physiology and pulmonary function testing
Respiratory physiology 28
Control of ventilation 41
Respiratory mechanics 48
Gas transfer 54
Arterial blood gas assessment 60
Exercise testing 70
Bronchial provocation testing 77
Static and dynamic lung volumes 83
Assessment for anaesthesia/surgery 90
3 – Diagnostic approach
Dyspnoea 97
Chest pain 108
Cough 110
Physical examination 117
4 – Diagnostic procedures
Bronchoscopy 124
Interventional pulmonology 132
Bronchoalveolar lavage 138
Medical thoracoscopy/pleuroscopy 145
Thoracentesis 151
Chest radiography and fluoroscopy 154
Transthoracic ultrasound 160
Lung CT and MRI 169
HRCT of the chest 175
Nuclear medicine of the lung 181
Sputum and exhaled breath analysis 187
Microbiology testing and interpretation 194
Laboratory diagnosis of mycobacterial infections 201
Biopsy 207
5 – General principles of treatment modalities and prevention
measures
Inhaled drug therapy 210
Systemic pharmacotherapy 215
Allergen-specific immunotherapy 223
Immunotherapies in lung cancer 227
Respiratory physiotherapy 232
Pulmonary rehabilitation 239
Palliative care 249
Oxygen therapy 253
Smoking-related diseases 257
Treatment of tobacco dependence 261
Long-term ventilation 266
Pleural infection and lung abscess 273
Endoscopic lung volume reduction 282
Lung transplantation 288
6 – Respiratory emergencies
Respiratory emergencies 293
Lung injury and acute respiratory distress syndrome 299
7 – Airway diseases
Upper airway disease 304
Asthma 308
Bronchitis 320
COPD and emphysema 324
Exacerbations of COPD 332
Extrapulmonary effects of COPD 339
Pharmacology of asthma and COPD 344
Bronchiectasis 353
Rare airway diseases 358
Congenital airway disease 364
8 – Respiratory infections
Upper respiratory tract infections 372
Pneumonia 377
Hospital-acquired pneumonia 383
Pneumonia in the immunocompromised host 388
Influenza, pandemics and SARS 393
Opportunistic infections in the immunocompromised host 400
Aspiration pneumonitis 411
9 – Mycobacterial diseases
Pulmonary tuberculosis 416
Tuberculosis in immunocompromised patients 429
Extrapulmonary tuberculosis 433
Latent tuberculosis 438
Nontuberculous mycobacterial disease 442
10 – Thoracic tumours
Pathology and molecular biology of lung cancer 447
Lung cancer: diagnosis and staging 453
Chemotherapy and molecular biological therapy 463
Surgical treatment for lung cancer 472
Radiotherapy for lung cancer 481
Other lung tumours 490
Metastatic tumours 495
Pulmonary nodules 501
Pleural and chest wall tumours 506
Mediastinal tumours 514
11 – Sleep and control of breathing disorders
Obstructive sleep apnoea–hypopnoea syndrome 522
Central sleep apnoea 529
Hypoventilation syndromes 535
12 – Respiratory failure
Respiratory failure 541
NIV in acute respiratory failure 546
13 – Diffuse parenchymal lung diseases
Idiopathic pulmonary fibrosis 553
Hypersensitivity pneumonitis 557
Sarcoidosis 563
Idiopathic interstitial pneumonias 568
Adult pulmonary Langerhans cell histiocytosis 581
Lymphangioleiomyomatosis 585
Pulmonary alveolar proteinosis 589
Amyloidosis 592
Drug-induced and iatrogenic respiratory disease 595
Radiation-induced lung disease 612
Eosinophilic diseases 615
14 – Pulmonary vascular diseases
Pulmonary embolism 620
Pulmonary hypertension 628
Pulmonary vasculitis 637
Arteriovenous malformations 646
15 – Diseases of the chest wall and respiratory muscles
Chest wall disorders 649
Neuromuscular disorders and the diaphragm 653
16 – Pleural and mediastinal diseases
Pleural effusion 660
Pneumothorax and pneumomediastinum 666
Mediastinitis 671
17 – Respiratory consequences of systemic/extrapulmonary conditions
Pulmonary diseases in primary immunodeficiency syndromes 675
HIV-related disease 681
Cardiac disease 692
Gastrointestinal and liver disease 701
Haematological diseases 707
Obesity 716
Connective tissue diseases 722
18 - Genetic disorders
Cystic fibrosis 727
Primary ciliary dyskinesia 740
α1-antitrypsin deficiency 744
19 - Occupational diseases
Occupational diseases 748
20 - Epidemiology, environment and lifestyle
Measuring the occurrence and causation of respiratory diseases 753
Indoor and outdoor pollution 771
High altitude and diving-related diseases 779