Isolated Liver Perfusion For Hepatic Tumors

This volume informs about different techniques of isolated liver perfusion already used in clinical practice. Indications for liver perfusion are discussed from pathological, oncological and surgical viewpoints. Special aspects of anesthesia and postoperative management in the intensive care unit are explained. The pathophysiology of hyperthermia, chemotherapeutics and tumor necrosis factor in isolated liver perfusion are described. First clinical results including the use of tumor necrosis factor in combination with melphalan are reported. The radiological methods of postoperative monitoring of tumor necrosis after therapy are presented. TOC:From the Contents: Indication.- Are There Indications for Intraarterial Hepatic Chemotherapy or Isolated Liver Perfusion? The Case of Liver Metastases from Colorectal Cancer. Indications for Isolated Hyperthermic Liver Perfusion: A Surgeon's View. Techniques/Anaesthesia.- Asanguineous Isolated Hyperthermic Perfusion of the Liver: Results of an Experimental Study in Pigs. Hyperthermo-Chemo-Hypoxic Isolated Liver Perfusion for Hepatic Metastases: A Possible Adjuvant Approach. The Surgical Technique of Isolated Hyperthermic Arterial Liver Perfusion in Humans. Monitoring Leakage During Isolated Hepatic Perfusion. Anesthesiological Management During Isolated Liver Perfusion. High-Dose Chemoperfusion.- Percutaneous Isolated Liver Chemoperfusion for Treatment of Unresectable Malignant Liver Tumors: Technique, Pharmacokinetics, Clinical Results. Phase I/II Studies of Isolated Hepatic Perfusion with Mitomycin C or Melphalan in Patients with Colorectal Cancer Hepatic Metastases.