Human Gonadotropins

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. Dr. Butler attained his PhD from the University of London and after a Post-Doctoral Fellowship at Yale University School of Medicine he became an Assistant Professor at the University of New Mexico with the USA hCG Reference Service. Steve returned to the UK and, following positions at Queen Mary University of London and London Metropolitan University he spent seven years at Middlesex University as Reader (Associate Professor) in Biomedical Diagnostics. Dr Butler has been a Director for medical diagnostics companies and and is now a consultant biomedical diagnostics expert with a particular interest in diagnostics and therapeutics relating to hCG in pregnancy and cancer. He has published over 80 peer reviewed scientific articles, reviews, letters, patents, abstracts and book chapters in the field of molecular diagnostics. He is a global opinion leader on the structure and function of human chorionic gonadotropin (hCG) and its role as a diagnostic marker in fertility, pregnancy and cancer.

A. Evolution1. Evolution of Aa, GAH, FSH and LH2. Evolution of CG and Development of HumansB. Structure of the Gonadotropins3. Structure FSH Peptide/arbohydrate/3D Construction4. Structure LH Peptide/Carbohydrate/3D Construction5. Structure hCG Peptide/Carbohydrate/3D Construction6. Multiple forms of hCG Peptide/Carbohydrate/3D ConstructionC. Synthesis of the Gonadotropins7. Synthesis of the GonadotropinsD. Functions of the Gonadotropins8. Functions of Gonadotropin Releasing Hormone and Inhibin9. Function of FSH10. Function of LH11. Function of Hormone hCG12. Function of Hyperglycosylated hCG and Extravillous Cytotrophoblast hCGE. Degradation of the Gonadotropins13. Degradation hCGF. Antibodies and Immunoassays for the Gonadotropins14. Antibodies and Immunoassays for hCGG. Commercial products and standards for Gonadotropins15. Commercial Products and Standards for FSH16. Commercial Products and Standards for LH17. Commercial Products and Standards for hCGH. The Genetics of Gonadotropins18. The genetics of FSH19. The genetics of hCG and LHI. Sex Steroid Hormones20. Estrogens and Progestogens21. Male SteroidogenesisJ. Female Reproduction22. Female reproduction: Follicle Formation and Follicle Selection23. Female reproduction: Ovulation and Luteinization24. Fertilization and Blastocyst Formation25. Illicit use of hCG in Dietary Programs and to Promote AnabolismK. Male Reproduction26. Male Reproduction: sperm formation27. Sperm ActivationL. Adrenarche and Menarche28. Adrenarche and Menarche in Girls29. Adrenarche and Puberty in BoysM. Menstrual Cycle hCG30. Pituitary Sulfated hCG31. Hyperglycosylated hCG and Extravillous Cytotrophoblast hCGN. Pregnancy32. hCG and Pregnancy Tests33. False-positive hCG Pregnancy Tests34. hCG and Pregnancy35. Implantation and Pregnancy Failure36. Deep Implantation, hCG and Gestational Hypertension, PreeclampsiaO. Roles of Gonadotropins in Reproduction and Cancer37. hCG and Gestational Trophoblastic Diseases38. The Human Brain: Sexuality39. Ovarian Cystic Disorders40. hCG and Choriocarcinoma41. hCG and CancerP. Receptors and intermediaries for Gonadotropins42. Hyperglycosylated hCG, Extravillous Cytotrophoblast hCG and TGFß Receptor 243. Receptor and Intermediators for FSH44. Receptor and Intermediaries for LH and the Hormone hCG