Immunotherapeutic Strategies for the Treatment of Glioma

Dr. Jackson is a senior resident in Neurosurgery at Johns Hopkins. He obtained his MD from the Johns Hopkins University School of Medicine. He completed his chief residency in June 2018 and is currently working as a postdoctoral fellow in neuro-oncology. His research interests focus on interactions between brain tumors and the host immune system, particularly local, regional, and systemic mechanisms of immune suppression Dr. Lim is a Professor of Neurosurgery, Oncology, Otolaryngology, and Radiation Oncology at Johns Hopkins. He obtained his MD from the Johns Hopkins University School of Medicine. He then completed his residency in Neurosurgery at Stanford University Hospital. Dr. Lim’s surgical interest is in both benign and malignant brain tumors, with a particular interest in gliomas (including ependymoma), meningioma, pituitary tumors and skull base tumors. Dr. Lim is the Director of the Brain Tumor Immunotherapy Program at Johns Hopkins. His primary research interest is developing immune-based therapies against brain tumors. His research laboratory is focused on understanding the mechanisms of immune evasion by primary brain tumors. Findings from his laboratory are directed towards translation to novel therapies against brain tumors. In addition to running a laboratory, he also directs the immunotherapy clinical trials program at Johns Hopkins. He currently serves as the principal investigator of several large brain tumor immunotherapy clinical trials based on findings from his laboratory.

1. Peptide vaccines 2. Dendritic cell vaccines 3. Heat shock protein vaccines 4. Immune checkpoint blockade 5. Targeting myeloid cells in glioblastoma 6. Oncolytic viruses 7. CAR T cell therapy 8. Mechanisms of immune suppression in glioblastoma patients 9. Immunogenomics in glioblastoma