Intraoperative Radiotherapy

This monograph reports on a clinical series in which intraoperative radiation therapy was used in multidisciplinary treatment programmes for tumours of various sites and differing histological sub-types. The present status of the modality is assessed and future developments are appraised.

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This monograph reports on the largest clinical series to date in which intraoperative radiation therapy (IORT) has been used in multidisciplinary treatment programmes for tumours of various sites and differing histological subtypes. It represents the product of 5 years' intensive work by physicians active at a leading European institution. The findings are supplemented by a thorough review of the data presented during the last two decades. The results in the book focus on the most important features of clinical research reports based on phase I-II studies (toxicity, local tumour control and survival data). The tumour sites and histologies analyzed are head and neck cancer, lung cancer, gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer, gynaecologic cancer, soft tissue sarcomas of the extremities, retroperitoneal and other central soft tissue sarcomas, Ewing's sarcoma, osteosarcoma and intracranial tumours.