Molecular Hematology (eBook)

DREW PROVAN, MD, FRCP, FRCPath, is Emeritus Reader in Autoimmune Haematology, Department of Haematology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK. JOHN G. GRIBBEN, MD, DSc, FRCP, FRCPath, FMedSci, is The Gordon Hamilton Fairley Professor of Medical Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

Contributors ix

Preface to the fourth edition xiii

Further reading xv

Acknowledgments xvi

1 Beginnings: the molecular pathology of hemoglobin 1
David Weatherall

2 Stem cells 21
David T. Scadden

3 The genetics of acute myeloid leukemias 37
Amy M. Trottier & Carolyn J. Owen

4 Molecular diagnostics and risk assessment in myeloid malignancies 49
Christian Scharenberg & Torsten Haferlach

5 Molecular basis of acute lymphoblastic leukemia 59
Bela Patel & Fiona Fernando

6 Chronic myeloid leukemia 71
Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O'Brien

7 Myeloproliferative neoplasms 87
Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey

8 Lymphoma genetics 101
Jennifer L. Crombie, Anthony Letai & John G. Gribben

9 The molecular biology of chronic lymphocytic leukemia 111
John G. Gribben

10 The molecular biology of multiple myeloma 121
Wee Joo Chng & P. Leif Bergsagel

11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131
Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris

12 Anemia of chronic disease 155
Tomas Ganz

13 The molecular basis of iron metabolism 161
Nancy C. Andrews & Tomas Ganz

14 Hemoglobinopathies due to structural mutations 173
D. Mark Layton & Steven Okoli

15 Molecular pathogenesis of malaria 193
David J. Roberts, Arnab Pain & Chetan E. Chitnis

16 Molecular coagulation and thrombophilia 207
Björn Dahlbäck & Andreas Hillarp

17 The molecular basis of hemophilia 221
Daniel P. Hart & Paul L.F. Giangrande

18 The molecular basis of von Willebrand disease 235
Luciano Baronciani

19 Platelet disorders 251
Kenneth J. Clemetson

20 The molecular basis of blood cell alloantigens 267
Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown

21 Functions of blood group antigens 285
Jonathan S. Stamler & Marilyn J. Telen

22 Autoimmune hematological disorders 297
Drew Provan & John W. Semple

23 Molecular therapeutics in hematology: gene therapy 319
William M. McKillop & Jeffrey A. Medin

24 Pharmacogenomics 339
Leo Kager & William E. Evans

25 History and development of molecular biology 353
Paul Moss

26 Cancer stem cells 363
Sara Ali & Dominique Bonnet

27 Molecular basis of transplantation 373
Francesco Dazzi & Antonio Galleu

Index 389