Tumor Microenvironment

The Main Driver of Metabolic Adaptation

Buch | Hardcover

VII, 443 Seiten

2020 | 1st ed. 2020
Springer International Publishing (Verlag)
978-3-030-34024-7 (ISBN)

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The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics.

In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. Themetabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book.

The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Jacinta Serpa is an Assistant Professor and Senior Researcher at the Universidade Nova de Lisboa.

Preface.- Tumor microenvironment a job of several holders.- Tumor microenvironment- a selective pressure boosting cancer.- Lactate and lactate transporters as key players in the maintenance of the Warburg effect.- Section 1. Adaptive metabolic features are sustained by tumor microenvironment.- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis.- Gut microbiota and cancer of the host: colliding interests.- Metabolic plasticity of tumor cells: how they do adapt to food deprivation.- Multifaceted oncogenic role of adipocytes in the tumour microenvironment.- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology.- Monocytes and macrophages in cancer: unsuspected roles.- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression.- Microenvironment driven metabolic adaptation in melanoma.- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis.- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt.- The bone marrow niche - the tumor microenvironment that ensures leukemia progression.- Section 3. Metabolic fitness and therapy response in cancer.- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer.- The metabolic remodelling in lung cancer and its putative consequence in therapy response.- Hydrogen sulfide metabolism and signaling in the tumor microenvironment.- Using metabolic adaptation to design new drugs.- Metabolomics- a new way of screening cancer.- NMR as a tool for metabolomics.- Section 5. Animal models- addressing cancer microenvironment.- Animal models to study cancer and its microenvironment.- Modulating the metabolic phenotype of cancer microenvironment.- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.- Section 6. In vitroand ex vivo cancer models.- In vitro and ex vivo models- the tumor microenvironment in a flask.- Index.

Erscheinungsdatum	06.03.2020
Reihe/Serie	Advances in Experimental Medicine and Biology
Zusatzinfo	VII, 443 p. 1 illus.
Verlagsort	Cham
Sprache	englisch
Maße	178 x 254 mm
Gewicht	1383 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizin / Pharmazie ► Studium
Schlagworte	Cancer Metabolism • cell survival • intercellular cooperation • metabolic signaling • Metabolomics
ISBN-10	3-030-34024-4 / 3030340244
ISBN-13	978-3-030-34024-7 / 9783030340247
Zustand	Neuware