Wound Healing, Tissue Repair, and Regeneration in Diabetes

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others. Amitava Das, PhD, is a Postdoctoral Researcher at Indiana Center for Regenerative Medicine and Engineering (ICRME), Indiana University School of Medicine. Dr. Das earned his Bachelor’s and Master’s in Pharmacy and Pharmaceutical Chemistry, respectively, from PES College of Pharmacy, Bangalore, India. He earned his PhD degree in Human Nutrition from The Ohio State University in 2016 after which he joined as a Postdoctoral Researcher in Department of Surgery at The Ohio State University Medical Center, and then moved to Indiana University in 2018. His research interests are tissue repair and regeneration in diabetes and Nutraceuticals. He has published over 20 research papers and numerous book chapters. Since 2017, Dr. Das is a member of the Editorial Board of Journal of American College of Nutrition and a Communications committee member of the Wound Healing Society. Dr. Das also serves as a reviewer for multiple prestigious journals. He has presented at various national and international conferences and is the recipient of several awards. Sashwati Roy, PhD is a Professor of Surgery and Director of Laser Capture Molecular Analysis facility at the Ohio State University Columbus Ohio. She received her PhD in 1994 in Physiology and Environmental Sciences. She completed her postdoctoral training from University of California, Berkeley. Her research interest include wound inflammation, mechanisms of resolution of diabetic wound inflammation, role of miRNA in tissue repair processes. Dr. Roy has over 150 peer review publications in high impact journals including Nature Nanotechnology, PNAS and Journal of Immunology. Dr. Roy is the President Elect of the Wound Healing Society. She serves in the Editorial Board of several Journals such as Physiological Genomics, Antioxidants and Redox Signaling. She is an expert in significance of macrophage and inflammation in chronic wounds. Dr. Roy’s research is funded by National Institute of Health (NIDDK, NIH).

Part 1: Background and Overview 1. Concept and stages of wound healing 2. Pathophysiology of Diabetic ulcers 3. Wound infection and inflammation 4. The Angiogenic Response 5. Fetal Wound Healing 6. The Extracellular matrix: its formation and role in wound healing 7. Scarring and fibrosis 8. Role of cytokines and chemokines in wound healing 9. Dysregulated inflammation in diabetic wounds 10. Role of oxygen in diabetic wound healing 11. Epigenetics of diabetic wound healing 12. Tissue regeneration 13. Energetics and nutritional status of chronic and diabetic wounds 14. Epidemiology of Diabetic wounds

Part Two: Clinical Update and Therapeutic Standards 15. Wound management and its principles 16. Chronic wounds and its menaces 17. Surgical Debridement and NPWT 18. Clinical management of DFU 19. Diabetic neuropathy 20. Malignant wounds

Part Three: Therapeutic Interventions 21. Biomaterials used to treat diabetic wounds 22. Peptides to treat diabetic wounds 23. Nutraceutical interventions of wound healing and inflammation 24. Papaya: A natural remedy for diabetic wounds 25. Role of berries in wound healing

Part Four: Future Directions 26. MiRNA in diabetic wound healing 27. Electroceuticals: an emerging field in wound healing 28. Nano-electroporation and reprogramming