Huntington's Disease

Examining the basic science and clinical management of Huntington's disease, this work includes coverage of developments in the molecular biology of the condition following isolation of the gene, and implications for prediction and genetic counselling as well as therapy.

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Huntington's Disease is a genetic disorder characterized by involuntary movements and mental deterioration resulting from widespread degenerative changes, particularly in the basal ganglia and cerebral cortex. Since the publication of the widely acclaimed First Edition of Peter Harper's book, the isolation of the gene has revolutionized our understanding of the disease. All the new work and its implications for management of the disorder are included in this state-of-the-art monograph. The strengths of the First Edition are retained, thus the book retains its comprehensive multidisciplinary coverage of clinical neurology, molecular biology, neurobiology, psychiatric aspects and genetic counselling. Features: * Includes the most recent developments in the molecular biology following isolation of the gene, and implications for prediction and genetic counselling as well as therapy. * Written by world-renowned research group.