Prognostic and Predictive Factors in Breast Cancer

Rosemary A. Walker, Alastair M. Thompson

Introduction / Overview. Role of the Pathologist in Assessing Prognostic Factors for Breast Cancer. Determination and Significance of Lymph Node Occult Metastasis in Breast Cancer. Prognostic Value of Proliferation and Apoptosis in Breast Cancer. The Role of Cell-Cell and Cell-Stromal Interactions in Predicting Breast Cancer Behavior. Detection of Minimal Residual Disease in Predicting Outcome in Breast Cancer. Allelic Imbalance / Microsatellite Instability in Breast Cancers and Blood Determining Breast Cancer Behavior. The Use of Steroid Receptors in Predicting Response to Hormonal Therapy. MAP Kinase Family Members and Endocrine Response and Survival in Breast Cancer. p53 and Breast Cancer. Assessment of HER-2 and its Value in Breast Cancer.