Drug-Induced Liver Disease

Drug-Induced Liver Disorders: Introduction and Overview
Neil Kaplowitz
The Role of Cytochrome P450s in Drug-Induced Liver Disease
Paul B. Watkins
Oxidative Stress, Antioxidant Defense, and Liver Injury
Hartmut Jaeschke
Hepatotoxicity Due to Mitochondrial Injury
Dominique Pessayre, Abdellah Mansour, Bernard Fromenty, and Alain Berson
Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
Neil Kaplowitz
The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis
Peter L.M. Jansen and Michael Müller
Immunological Mechanism in Liver Injury
Petra Obermayer-Straub and Michael Peter Manns
Mechanistic Role of Acyl Glucuronides
Chunze Li and Leslie Z. Benet
Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity
Debra L. Laskin and Carol R. Gardner
Roles of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis after Liver Injury
Rebecca Taub, Meena Bansal, and Wei Lei
Clinicopathological Patterns of Drug-Induced Liver Disease
Willis C. Maddrey
Histopathology of Drug-Induced Liver Disease
Gary C. Kanel
Mechanisms of Acetaminophen-Induced Liver Disease
Sidney D. Nelson and Sam A. Bruschi
Acetaminophen: Pathology and Clinical Presentation of Hepatoxicity
William A. Lee and George Ostapowicz
Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs
Urs A. Boelsterli
Nonsteroidal Anti-Inflammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity
James H. Lewis
Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity Of Anesthetic Agents
J. Gerald Kenna
Anticonvulsant Agents
J. Steven Leeder and Munir Pirmohamed
Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse
Kia Saeian and K. Rajender Reddy
Antibacterials and Antifungal Agents
Jean Frederic Westphal and Jean Marie Brogard
Antituberculous Agents-Induced Liver Disease
Pramod Kumar Garg and Rakesh Kumar Tandon
Hepatic Injury from Antiviral Agents
Maurizio Bonacini, Stan Louie, and Kevin Weissman
Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Felix A. de la Iglesia, Jeffrey R. Haskins, and George Feuer
Cancer Chemotherapy
Laurie D. DeLeve
Immunomodulating Agents and the Transplant Situation
Mary F. Hebert, Shari L. Taylor, and Robert L. Carithers, Jr.
Methotrexate Controversies
Adrian Reuben
Adverse Effects of Hormones and Hormone Antagonists on the Liver
Muhammad Naeem and Steven Schenker
Alternative Medicine, Vitamins, and Natural Hepatotoxins
Georges-Philippe Pageaux and Dominique Larrey
Occupational and Environmental Hepatotoxicity
Keith G. Tolman
Regulatory Perspectives
John R. Senior
Index