Severe Asthma

Kian Fan Chung is Professor of Respiratory Medicine and Head of Experimental Studies at the National Heart and Lung Institute, Imperial College London (London, UK). He is also an Honorary Consultant Respiratory Physician at the Royal Brompton and Harefield NHS Trust (London, UK), and a Senior Investigator of the UK National Health Service National Institute for Health Research. Elliot Israel is the Gloria and Anthony Simboli Distinguished Professor in Asthma Research and Professor of Medicine at Harvard Medical School (Boston, MA, USA), and the Director of Clinical Research in the Pulmonary and Critical Care Division at the Brigham and Women’s Hospital (Boston, MA, USA). He directs the Brigham and Women’s Hospital Severe Asthma Program. Peter G. Gibson works as a doctor who cares for people with respiratory diseases and as a clinical scientist investigating the mechanisms and treatment of asthma, COPD, cough and other airway disorders. He is a concept leader who has developed innovative approaches around: inflammatory subtypes of asthma and cough; airway biomarkers; neurogenic mechanisms, laryngeal dysfunction and related treatments for refractory cough; multidimensional assessment and management of complex airway disorders such as severe asthma, airways diseases in the elderly; and asthma in pregnant women.

Defintion and impact; Understanding the experience of people living with severe asthma; The contribution of comorbidities, psychosocial factors and adherence; Clinical phenotypes: adults; Clinical phenotypes: children; Mechanisms underlying fixed airflow obstruction and exacerbations; Clinical biomarkers and noninvasive assessment; Imaging; Pathophysiology; The lessons from U-BIOPRED; SARP: dissecting subphenotypes and endotypes; Molecular phenotypes; Metabolic dysfunction; Corticosteroid responsiveness and resistance; Mechanisms in children; Evaluation and management in children; Evaluation of difficult-to-treat and severe asthma in adults; Biologics targeting type 2 inflammation; Nonpharmacological interventions: behavioural and interventional approaches; Management in adults; The next decade of continuing progress; Case 1; Case 2; Case 3; Case 4