Osteoarthritis

1. Definition and classification of osteoarthritis ; 2. Epidemiology of osteoarthritis ; 3. The economics of osteoarthritis ; 4.1 EVIDENCE FOR THE INHERITANCE OF OSTEOARTHRITIS ; 4.2 Specific gene defects associated with osteoarthritis ; 4.3 Laboratory approaches to the identification of genetic association in osteoarthritis ; 5. Pathology of osteoarthritis ; 6. Paleopathology of osteoarthritis ; 7.1 INTRODUCTION: THE CONCEPT OF OSTEOARTHRITIS AS FAILURE OF THE DIARTHRODIAL JOINT ; 7.2 PATHOGENESIS OF STRUCTURAL CHANGES IN THE OSTEOARTHRITIC JOINT ; 7.2.1.1 BIOCHEMISTRY AND METABOLISM OF NORMAL AND OSTEOARTHRITIC CARTILAGE ; 7.2.1.2 Proteolytic degradation of normal and osteoarthritic cartilage matrix ; 7.2.1.3 Articular cartilage repair ; 7.2.1.4 Mechanical properties of normal and osteoarthritic articular cartilage, and the mechanobiology of chondrocytes ; 7.2.1.5 Response of the chondrocyte to mechanical stimuli ; 7.2.1.6 Crystals and osteoarthritis ; 7.2.2.1 SUBCHONDRAL BONE IN THE PATHOGENESIS OF OSTEOARTHRITIS. MECHANICAL ASPECTS ; 7.2.2.2 Subchondral bone in the pathogenesis of osteoarthritis. Biological effects ; 7.2.2.3 Systemic changes in bone in osteoarthritis ; 7.2.3.1 SYNOVIAL MEDIATORS OF CARTILAGE DAMAGE AND REPAIR IN OSTEOARTHRITIS ; 7.2.3.2 Synovial physiology in the context of osteoarthritis ; 7.2.4.1 INNERVATION OF THE JOINT AND ITS ROLE IN OSTEOARTHRITIS ; 7.2.4.2 Neuromuscular Protective Mechanisms ; 7.2.4.3 Proprioception in Osteoarthritis ; 7.2.5 Local mechanical factors in the natural history of knee osteoarthritis, malignment and joint laxity ; 7.3.1 PERIPHERAL AND CENTRAL PAIN MECHANISMS IN OSTEOARTHRITIS ; 7.3.2 Why does the patient with osteoarthritis hurt? ; 8.1 SIGNS, SYMPTOMS, AND LABORATORY TESTS ; 8.2 Plain radiographic features of osteoarthritis ; 8.3 The natural history and prognosis of osteoarthritis ; 9.1 INTRODUCTION: THE COMPREHENSIVE APPROACH ; 9.2 Systemic analgesics ; 9.3 The role of NSAIDs in the treatment of Osteoarthritis ; 9.4 Economic considerations in pharmacologic management of osteoarthritis ; 9.5 Topical NSAIDs ; 9.6 Topical capsaicin cream ; 9.7 Intra-articular glucocorticoids and other injection therapies ; 9.8 Intra-articular hyaluronan injection ; 9.9 Nutritional therapies ; 9.10 Mechanisms by which micronutrients may influence osteoarthritis ; 9.11.1 EXERCISE FOR PATIENT WITH OSTEOARTHRITIS ; 9.11.2 Other Physical Therapies ; 9.11.3 Other Physical Therapies ; 9.12 Occupational therapy for the patient with Osteoarthritis ; 9.13 Patient education ; 9.14 Social support ; 9.15 Depression in osteoarthritis ; 9.16 Coping strategies for the patient with osteoarthritis ; 9.17 Irrigation of the osteoarthritic joint ; 9.18 Surgical approaches to preserving and restoring articular cartilage ; 9.19 Arthroplasty and its complications ; 9.20 Weight loss and Osteoarthritis ; 9.21 Patient adherence ; 10. Outcome assessment in osteoarthritis: a guide for research and clinical practice ; 11.1 INTRODUCTION ; 11.2.1 THE BIOLOGICAL PERSPECTIVES ; 11.2.2 The clinical perspective ; 11.3 Advantages and limitations of animal models in the discovery and evaluation of novel disease-modifying osteoarthritis drugs (DMOADS) ; 11.4.1 RADIOGRAPHIC GRADING SYSTEMS ; 11.4.2 Quantitation of radiographic changes ; 11.4.3 Magnetic resonance imaging ; 11.4.4 Arthroscopic evaluation of knee articular cartilage ; 11.4.5 Bone Scintigraphy ; 11.4.6 Ultrasonography ; 11.4.7 Defining and validating the clinical role of molecular markers in osteoarthritis ; 12. Design of clinical trials for evaluation of structure modifying drugs and new agents for symptomatic treatment of osteoarthritis