Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications

Sheeba Varghese Gupta, MPharm, PhD, is an associate professor, Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida. She received her PhD at Wayne State University, Michigan, and earned her MS in Pharmaceutical Chemistry from Bharati Vidhya Peeth Poona College of Pharmacy, University of Pune, Maharashtra, India. Her research interests are novel drug delivery systems, improving oral absorption of poorly absorbed drugs, and patient outcomes. She has authored many peer-reviewed publications, book chapters and abstracts. Dr. Yashwant V. Pathak completed his PhD in Pharmaceutical Technology at Nagpur University, India, and EMBA and MS in Conflict Management at Sullivan University. He is professor and associate dean for Faculty Affairs at Taneja College of Pharmacy, University of South Florida. Tampa, Florida. With extensive experience in academia as well as industry, he has more than 200 research publications, including research papers; chapters and reviews; 2 patent and 2 patent application; and 28 edited books published, including 12 books in nanotechnology and 10 in nutraceuticals and drug delivery systems. He has several books in cultural studies and conflict management. He has received several national and international awards. Dr. Pathak was a recipient of Fulbright Senior Scholar award for Indonesia in the year 2016–2017. Dr. Yashwant V. Pathak is also an adjunct professor at Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.

Contents

Preface......................................................................................................................vii

Editors .......................................................................................................................ix

Contributors ..............................................................................................................xi

Chapter 1 Role of Micronutrients in Cancer Prevention and

Intervention—Pros and Cons ...............................................................1

Anjelika Chatwal and Yashwant V. Pathak

Chapter 2 Nutraceuticals as Supplements for Cancer Prevention ....................... 19

Nicholas Micciche, Brianna Choyce, and Yashwant V. Pathak

Chapter 3 Nutraceutical’s Role in Proliferation and Prevention

of Prostate Cancer .............................................................................. 39

Raghunandan Yendapally and Donald Sikazwe

Chapter 4 Nutraceutical’s Role in Proliferation and Prevention

of Colorectal Cancer .......................................................................... 61

Mayur M. Patel, Shruti U. Rawal, and Jayvadan K. Patel

Chapter 5 Nutraceuticals’ Role in Proliferation and Prevention

of Breast Cancer ............................................................................... 115

Sadaf Aslam and Beata Casanas

Chapter 6 Nutraceutical’s Role in Proliferation and Prevention

of Gynecological Cancers ................................................................ 133

Aaishwarya B. Deshmukh, Jayvadan K. Patel, and Bharat Mishra

Chapter 7 Mechanism and Role of Probiotics in Suppressing

Bowel Cancer ..............................................................................153

Aaishwarya B. Deshmukh, Jayvadan K. Patel, and Bharat Mishra

Chapter 8 Effect of Nutraceuticals on Gut Microbiota—What Is the

Deal in Cancer? ................................................................................ 171

Andréa Burgess, Asra Sami, and Sheeba Varghese Gupta

Chapter 9 Nutrigenomics and Nutrigenetics in Cancer Prevention .................. 191

Komal Parmar and Jayvadan K. Patel

Chapter 10 Novel Drug Delivery Systems for Nutraceuticals with

Anticancer Properties .......................................................................207

Priyanka Bhatt, Imran Vhora, and Rohan Lalani

Chapter 11 Delivery Strategies and Formulation Approaches of

Anticancer Nutraceuticals ................................................................ 239

Sunita Dahiya and Rajiv Dahiya

Chapter 12 Efficacy, Safety, and Toxicological Aspects of Nutraceuticals ........269

Jayvadan K. Patel and Anita Patel

Chapter 13 Dietary Habits and Susceptibility to Various Cancers ..................... 291

Kimberly Padawer and Yashwant V. Pathak

Chapter 14 Indian Diet and Cancer Prevention ..................................................307

Vasudha Pritipaul, Asra Sami, and Sheeba Varghese Gupta

Chapter 15 Dietary Isoflavones-Mechanism and Efficacy in Cancer

Prevention and Treatment ................................................................. 325

Richa Dayaramani and Jayvadan K. Patel

Index ...................................................................................................................... 341