Resistance to Targeted Therapies in Lymphomas

Dr. Ana C. Xavier is an Associate Professor at the Division of Hematology/Oncology, Department of Pediatrics at the University of Alabama at Birmingham (Birmingham, Alabama). She received her medical degree from the University of Sao Paulo, Brazil. She completed her pediatric residency at the Medical University of South Carolina and Pediatric Hematology/Oncology fellowship training at the Wayne State University. Dr Xavier is board certified in Pediatrics and Pediatric Hematology/Oncology and currently serves as Associate Program Director of the Pediatric Hematology/Oncology Fellowship Program at the University of Alabama at Birmingham. She has authored numerous peer-reviewed manuscripts in highly reputed international journals and has presented several abstracts at various national and international conferences. She holds memberships with the American Academy of Pediatrics, American Society of Hematology, American Society of Pediatric Hematology/Oncology and Children's Oncology Group. Dr. Xavier's clinical practice includes both pediatric oncology and her research interest focus on the treatment of pediatric patients with lymphoma. Mitchell S. Cairo is currently the Associate Chairman and Professor (with tenure) in the Department of Pediatrics at New York Medical College (NYMC). His additional current leadership positions include being the Chief of the Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Program Director of the Adult & Pediatric BMT Program, Director of the Childhood and Adolescent Cancer and Blood Disease Center, Medical and Scientific Director of the GMP Cellular and Tissue Engineering Laboratory at Westchester Medical Center (WMC), Medical Director of the WMC Hematotherapy Program and Co-Chair of the WMC Cancer Committee. Dr. Cairo's additional academic appointments include being a Professor of Medicine, Pathology, Microbiology and Immunology and Cell Biology and Anatomy and Public Health at NYMC. Briefly, Dr. Cairo's past education includes his undergraduate studies at the University of Wisconsin, Madison, WI, graduating in 1972 with a BA and election to Phi Beta Kappa. Dr. Cairo received his medical school training at the University of California, San Francisco (USCF) graduating in 1976 and election to Alpha Omega Alpha (AOA). Dr. Cairo trained as a Pediatric Resident at UCLA Harbor General from 1976-1978 under the mentorship of Joseph St. Geme, MD and then a Chief Residency in Pediatrics from 1978-1979 at UCSF under the mentorship of Melvin Grumbach, MD. Dr. Cairo completed a Pediatric Hematology-Oncology Fellowship as an American Cancer Society Fellow at Indiana University from 1979-1981 under the mentorship of Robert Baehner, MD. Dr. Cairo joined the faculty of Children's Hospital of Orange County (CHOC) in 1982 and established the BMT/Stem Cell Transplant program there in 1985 as Director of Blood and Marrow Transplantation. Also, at CHOC Dr. Cairo was the Principal Investigator (PI) for Children's Cancer Group and PI of the Cord Blood Collection Center and Cord Blood Transplant Center under an NHLBI award. In 1997, Dr. Cairo was recruited to Georgetown University where he became a Professor of Pediatrics, Medicine and Pathology and Chief of the Division of Stem Cell Transplantation, Cellular and Gene Therapy and Director of the Adult and Pediatric Bone Marrow Transplantation program at the Lombardi Cancer Center and Medical Director of the NHLBI Cord Blood Collection Center and Cord Blood Bank. In 2000, Dr. Cairo was recruited to Columbia University and was a Professor of Pediatrics, Medicine and Pathology and Director of the Division of Blood and Marrow Transplantation, member of the executive committee of the Department of Pediatrics, Medical Director of the National Marrow Donor Unrelated Transplant program, Chief of the Division of Pediatric Blood and Marrow Transplantation and member of the executive

Mechanisms of Glucocorticoid Response and Resistance in Lymphoid Malignancies.- Resistance to Monoclonal Antibody Therapeutics in Lymphoma.- Resistance to Antibody-Drug Conjugate.- Resistance to Proteasome Inhibitor Therapy in Non-Hodgkin Lymphoma.- Resistance to Histone Deacetylase Inhibitors in the Treatment of Lymphoma.- Resistance to Bruton's Tyrosine Kinase Signaling Pathway Targeted Therapies.- Resistance to Checkpoint Blockade Inhibitors and Immunomodulatory Drugs.- Resistance to Bispecific T-cell Engagers and Bispecific Antibodies.- Resistance to Chimeric antigen receptor T-cell therapy.- Index.