HLA-B27+ Spondyloarthropathies

Preface. Acknowledgements. Participants. I. Tolerance and Autoimmunity in Transgenic Mice. 1. Distinct Mechanisms of Peripheral Tolerance in Transgenic Mice Depending on Tissue Specific Expression of the Self Antigen. 2. T Cell Tolerance to Peripherally Expressed Antigens Studied Using Transgenic Mice. II. Antigen Presentation and Other Functions of Class I MHC Molecules. 3. Hybrid Genes as a Tool for Structural and Functional Analysis HLA-B27. 4. Structural and Functional Implications of Surface Binding of Peptide to Class 1 MHC. 5. Recognition of Human MHC Molecules by Murine T Cells from HLA and Human CD4 Transgenic Mice. 6. Class 1 MHC Molecules as Signaling Structures. III. B27 Transgenic Animals. 7. Expression and Function of HLA-B27 in Transgenic Mice. 8. Spontaneous Multi-Organ System Inflammatory Disease in HLA-B27 Transgenic Rats. 9. Joint Disease in B27 Transgenic Mice. IV. Bacterial Pathogenesis and Molecular Mimicry. 10. The Host Response to Mycobacterial Infections: Role of Stress Proteins. 11. A Role for HSP-60 Reactive gammadelta T Cells in Autoimmunity? 12. Synovial T Cell Reactivity to Bacterial Antigens and Stress Proteins. 13. Bacterial Antigens in Reactive Arthritis: Studies on Yersinia-and Salmonella-Triggered Arthritis. 14. Lessons From Studying Molecular Mimicry. 15. Enteric Disease and Reactive Arthritis: a 2mDa Plasmid Associated with Arthritogenic Shigella Strains Encodes an Epitope shared with HLA-B27. V. Clinical Aspects Of The Spondyloarthropathies. 16. Heterogeneity and a Wider Spectrum of Ankylosing Spondylitis and Related Disorders. 17. Newer Clinical, Epidemiological and Genetical Findings in Ankylosing Spondylitis and Related Spondylarthropathies. 18. Clinical Features of Ankylosing Spondylitis in Males and Females. 19. Ankylosing Spondylitis of Juvenile Onset. 20. Chlamydia-Induced Arthritis. The Clinical Spectrum, Serology and Prognosis. 21. Microbial-MHC Interactions in the Pathogenesis of Reactive Arthritis. 22. Disturbed Cartilage Matrix Metabolism in Reactive Arthritis. 23. Gut Inflammation in the Spondylarthropathies: Relation of the Different Types of Histological Inflammation to the Clinical Expression of the Disease. 24. Treatment of Seronegative Spondyloarthropathies: Is There Anything New? VI. Impact And Management Of Ankylosing Spondylitis. 25. Physiotherapy For Ankylosing Spondylitis - Exercise Program Development in Ankylosing Spondylitis. Assessment and Measurement of Outcome. Hydrodynamics in the Treatment of HLA-B27 Related Diseases. 26. Psychosocial Sequelae in Ankylosing Spondylitis. 27. Vocational Management in Ankylosing Spondylitis. 28. Adapting to Ankylosing Spondylitis. Author Index.