Human Cell Transformation

Johng S. Rhim, MD Associate Director, Center for Prostate Disease Research (CPDR), Research Professor Emeritus, Department of Surgery and Uniformed Service University of the Health Sciences (USUHS). Dr. Rhim has served as an associate director, the CPDR and professor of surgery in the department of surgery at the USUHS, in Bethesda, MD, a state-of-art translational research program that studies prostate cancer and prostate disease in the military healthcare system. Working in this capacity since 1999, he has also been a research professor in the department of surgery since 2000. Dr. Rhim spent 12 years as a project director of cancer research at Microbiological Associates, and 20 years as a senior investigator for the National Cancer Institute, both located in Bethesda, MD. He is an internationally recognized pioneer in the field of human cell transformation and his success in the development of cell culture systems has opened this field to the analysis of cellular, molecular and genetic mechanism of actions of chemical carcinogens, oncogenes and radiation.

Mechanisms underlying metastatic pancreatic cancer.- Current Perspectives on Nasopharyngeal Carcinoma.- An in Vitro Model of Triple Negative Breast cancer.- Emerging role of novel biomarkers of Ly6 gene family in pan cancer.- The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy.- Contributing roles of CYP2E1 and other cytochrome P450 isoforms in alcohol-related carcinogenesis.- Novel Human Prostate Epithelial Cell Cultures.- African American Prostate Normal and Cancer Cells for Health Disparities Research.- Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-Clinical Model for Prostate Cancer Research.- Role of alternative splicing in prostate cancer aggressiveness and drug resistance in African Americans.- Research Article: Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients.- The Aging Skeleton.- Parathyroid Hormone Related Protein (PTHrP):  an Emerging Target in Cancer Progression and Metastasis.- Targeting DNA hypomethylation in malignancy by epigenetic therapies.- Tumor Dormancy and Slow-Cycling Cancer Cells.- Resolution of Cellular Heterogeneity in Human Prostate Cancers: Implications for Diagnosis and Treatment.- Small molecule inhibition of glycogen synthase-kinase 3 in cancer immunotherapy.