Bile Acids and Their Receptors

Preface.- Part 1. Bile acids   as   signaling molecules  and their  receptors.- 1. A short history of bile acid pharmacology.- 2. Bile acids  activated receptors: a review of  GPBAR1  (TGR5) and other G-protein-coupled receptors.- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors.- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism.- 5. Signaling from intestine to  the host. How bile acids regulate intestinal and liver immunity.- Part 2.  General pharmacology of  bile acid activated receptors and their ligands.- 6. Modeling of bile acid activated receptors as a tool for pharmacological development.- 7. Chemistry and pharmacology of GPBAR1 and  FXR selective agonists, dual agonists and antagonists.- 8. Non steroidal FXR ligands: current status and  clinical applications.- 9.  Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases.- Part 3. Bile acids and their derivatives as drugs.- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications.- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile.- 12. Obeticholic acid: a review of   its mechanisms of action and  clinical applications.- Part 4. Bile acid activated receptors as therapeutic targets.- 13. Targeting FXR in cholestasis.- 14. FXR agonists for the treatment of NASH and other  metabolic disorders.- 15. Targeting bile acids activated receptors in bariatric surgery.