Haploidentical Transplantation

Stefan Ciurea is Associate Professor in the Department of Stem Cell Transplantation and Cellular Therapy at the University of Texas MD Anderson Cancer Center and leader of the Haploidentical Transplant Program at this institution. Dr. Ciurea received his medical degree from the Gr. T Popa University of Medicine and Pharmacy Iasi, Romania, and had Internal Medicine training at Harrisburg Hospital/PennState University, Fellowship in Hematology/Oncology at the University of Illinois at Chicago and Fellowship in Hematopoietic Stem Cell Transplantation and the University of Texas MD Anderson Cancer Center. He developed a Haploidentical Transplant Program at this institution with the goal to expand safe transplantation to all patients in need. Dr. Ciurea has made significant contributions in this field, primarily in identifying HLA antibodies as major cause of graft failure in mismatched transplantation and improving outcomes for patients with myeloid malignancies treated with hapl oidentical transplantation, and is principal investigator on multiple clinical trials.

Historical perspective and current trends in haploidentical transplantion.- Part 1: Graft manipulation and methods to control T-cell alloreactivity. -Positive CD34+ cell selection.- Selective allo-depletion: beta and CD19+ cell T cell depletion.- T cell addback in T- cell depleted haploidentical transplant.- Hematopoietic myeloid growth factor primed bone marrow and peripheral blood hematopoietic progenitor cells.- Photodepletion of allo-reactive T cells.- Post-transplant cyclophosphamide in haploidentical transplant.- Part 2: Ideal graft & donor.- Graft source: Marrow versus peripheral blood with PTCy- Does it matter?.- Anti-HLA antibodies: Assessment and mitigating strategies.- Selection of haploidentical donors: What is the art?.- Myeloablative versus non-myeloablative conditioning regimen- Does it matter and how best to select?.- Part 3: Disease-specific pediatric population.- Nonmalignant diseases in children.-