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A Handbook of Bioanalysis and Drug Metabolism

(Autor)

Buch | Softcover
416 Seiten
2004
Taylor & Francis Ltd (Verlag)
978-0-415-27520-0 (ISBN)
37,40 inkl. MwSt
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An invaluable guide for pharmacology students and professionals which will help to reinforce the theory in the subject of drug metabolism, and help develop valuable analytical and interpreting skills.
This stimulating new handbook examines the techniques, methodology and theory of bioanalysis and drug metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug-drug interactions. A Handbook of Bioanalysis and Drug Metabolism is an invaluable guide to senior undergraduates and postgraduates studying drug metabolism in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology - especially those considering industrial placements or a career in the biotechnology industry.

The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II Enzymes. In vitro Techniques for Investigating Metabolism. Drug to Drug Interactions: an in vitro Approach. Clinical Impact of Drug Interactions. PreClinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modelling in PreClinical Drug Discovery. Toxicokinetics. Protein Binding in PlasmaA Case History of a Highly Protein Bound Drug. Metabolite Identification by Spectroscopy. Whole Body Autoradiography. Radiolabelled Studies in Man. Molecular Biology.

Erscheint lt. Verlag 11.11.2004
Zusatzinfo 130 Line drawings, black and white; 12 Illustrations, black and white
Verlagsort London
Sprache englisch
Maße 174 x 246 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Laboratoriumsmedizin
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
ISBN-10 0-415-27520-2 / 0415275202
ISBN-13 978-0-415-27520-0 / 9780415275200
Zustand Neuware
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