Heme Oxygenase

Mahin D. Maines

AN OVERVIEW OF PORPHYRINS AND HEMES AND THEIR BIOSYNTHETIC PATHWAY. Introduction. Porphyrins and Metalloporphyrins-General Properties. d-Aminolevulinate Synthetase. d-Aminolevulinate Dehydratase. Porphobilinogen Deaminase and Uroporphyrinogen III Synthetase. Uroporphyrinogen III Decarboxylase. Coproporphyrinogen Oxidase. Protoporphyrin Oxidase. Ferrochelatase. Disorders of Porphyrin Metabolism (Porphyrias). References. BILIVERDIN REDUCTASE. Introduction. References. HEME OXYGENASE AND HEME DEGRADING SYSTEMS. Introduction. Nonenzymatic Degradation of Heme by Heme Oxygenase. Enzymatic Degradation of Heme by Heme Oxygenase. References. CHARACTERIZATION AND REGULATION OF HEME OXYGENASE ISOZYMES AT THE MOLECULAR LEVEL. Background. Molecular and Biochemical Properties of Heme Oxygenase Isozymes. Molecular Cloning and Characterization of HO-1 and HO-2. References. REGULATION OF HEME OXYGENASE ACTIVITY. RESULTANT MODULATING EFFECT ON HEMOPROTEIN-DEPENDENT FUNCTIONS. Introduction. Mechanisms of Heme Oxygenase Regulation. Consequences of Induction of Heme Oxygenase on Drug Steroid and Prostaglandin Metabolic Systems. References. NEONATAL JAUNDICE. Introduction: Jaundice in the Newborn. Factors Influencing Serum Bilirubin Levels in the Newborn. Toxicity of Bilirubin to the Newborn. Developmental Changes in Cellular Ability to Produce Bilirubin in the Newborn. Possible Physiological Importance of Bilirubin. Treatment of Hyperbilirubinemia. References.