The Hematopoietic Microenvironment

Offer a state-of-the-art review of the cellular and molecular basis of blood cell development. Topics discussed include cell types capable of elaborating haematopoietic growth factors, and their regulation of both growth factor production and matrix deposition, among others.

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Sophisticated cloning techniques now make it possible for investigators to study the production and development of blood at both the cellular and the molecular levels. In "The Hematopoietic Microenvironment", Michael Long and Max Wicha bring together a group of contributors to offer a state-of-the-art overview of the cellular and molecular basis of blood cell development. Topics examined in the book include cell types capable of elaborating hematopoietic growth factors, their regulation of both growth factor production and matrix deposition, and interactions of growth factors and haematopoietic progenitor cells with components of the extracellular matrix. Consideration is also given to the clinical implication of disorders of the haematopoietic microenvironment. Previously available largely in widely scattered journal articles and other difficult-to-reach sources, the up-to-date information in this book represents an important contribution to a field of growing importance. It should be of particular interest to professionals in haematology and oncology, as well as in molecular biology and genetics.