Pharmaceutical Biocatalysis

Peter Grunwald studied chemistry at the Universities of Saarbrücken and Hamburg, Germany. He graduated in the field of high-frequency spectroscopy and then became a staff member of the Institute of Physical Chemistry. After receiving his PhD in physical chemistry, he founded a biotechnology research group. He was appointed professor in 2001. His research interests focus on immobilized biocatalysts, kinetics of enzymes in organic solvents, and interactions between biocatalysts and heavy metal ions. Prof. Grunwald is also interested in chemical education, including curriculum development. He has authored a textbook on biochemistry and is an editorial board member of Catalysts.

Pharmaceuticals: Some General Aspects Use of Enzymes in the Downstream Processing of Biopharmaceuticals Therapeutic Use of Carbonic Anhydrase Inhibitors and Their Multiple Drug Interactions Fibrinolytic Enzymes for Thrombolytic Therapy Role of Engineered Proteins as Therapeutic Formulations Synthesis of bioactive peptides for pharmaceutical applications Cardiovascular Disease and Oxidative Stress Enzymatic Amino Acid Deprivation Therapies Targeting Cancer Carboxylesterase inhibitors: Relevance for Pharmaceutical Applications Molecular Aspects of the Activity and Inhibition of the FAD-containing Monoamine Oxidases Multifunctional Monoamine Oxidase and Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease The Neurodegenerative Characteristics of Alzheimer’s Disease and Related Multi-Target Drug Design Studies Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism Cytochrome P450 Enzymes for the Synthesis of Novel and Known Drugs and Drug Metabolites Cytochromes P450, Cardiovascular Homeostasis and Disease Protein Degradation Inducers SNIPERs and PROTACs against Oncogenic Proteins Resistance Mechanisms of Tumor Cells Biocatalytic Nanoreactors for Medical Purposes Computer-Aided Drug Design for the Identification of Multi-Target Directed Ligands (MTDLs) in Complex Diseases: An Overview The Development of Improved Therapeutics through a Glycan-‘Designer’ Approach On Biocatalysis as Resourceful Methodology for Complex Syntheses: Selective Catalysis, Cascades, and Biosynthesis