Introduction to Pharmaceutical Analytical Chemistry (eBook)
544 Seiten
Wiley (Verlag)
978-1-119-36275-3 (ISBN)
The definitive textbook on the chemical analysis of pharmaceutical drugs - fully revised and updated
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
- Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics
- Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject
- Examines various analytical techniques commonly used in pharmaceutical laboratories
- Provides practice problems, up-to-date practical examples and detailed illustrations
- Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines
Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.
STIG PEDERSEN-BJERGAARD is Professor at the Department of Pharmacy, University of Oslo and Professor at the Department of Pharmacy, University of Copenhagen.
BENTE GAMMELGAARD is Professor at the Department of Pharmacy, University of Copenhagen.
TRINE GRØNHAUG HALVORSEN is Associate Professor at the Department of Pharmacy, University of Oslo.
The definitive textbook on the chemical analysis of pharmaceutical drugs fully revised and updated Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals. This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension. Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject Examines various analytical techniques commonly used in pharmaceutical laboratories Provides practice problems, up-to-date practical examples and detailed illustrations Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.
STIG PEDERSEN-BJERGAARD is Professor at the Department of Pharmacy, University of Oslo and Professor at the Department of Pharmacy, University of Copenhagen. BENTE GAMMELGAARD is Professor at the Department of Pharmacy, University of Copenhagen. TRINE GRØNHAUG HALVORSEN is Associate Professor at the Department of Pharmacy, University of Oslo.
Symbols and Units
The units in the book do not strictly follow the SI units. The units are adjusted to the dimensions in analytical work.
Symbol | Unit |
A | Absorbance | — |
A(1%, 1 cm) | Specific absorbance | — |
AS | Symmetry factor | — |
a | Activity | — |
α | Relative retention (separation factor) | — |
Specific optical rotation | (°) degrees |
c | Concentration | g/L, mol/L |
d | Dextrorotary (optical rotation) | ° (degrees) |
D | Distribution ratio (also named distribution coefficient or partition coefficient) | — |
E | Potential | V |
E | Electrical field (CE) | V/cm |
E0 | Standard electrode potential (standard reduction potential) | V |
ε | Molar absorption coefficient | cm−1 · mol−1 · L |
εo | Relative elution strength | — |
η | Viscosity | cPoise |
F | Flow rate (chromatography) | mL/min |
F | Fluorescence | — |
h | Peak height | mm |
H | Height equivalent to theoretical plate |
I | Intensity | — |
IA | Acid value | mg |
II | Iodine value | mg |
IOH | Hydroxyl value | mg |
IS | Saponification value | mg |
Ka | Acid ionization constant (= acid dissociation constant, acidity constant) | M |
Kb | Base ionization constant (= basicity constant) | M |
KD | Partition ratio (= distribution constant) |
Kw | Autoprotolysis equilibrium constant of water (= ion product of water) | M2 |
k | Retention factor | — |
λ | Wavelength | nm |
L | Length | m (mm) |
l | Levorotary (optical rotation) | ° (degrees) |
μapp | Apparent mobility | cm2 · min−1 · V−1 |
μe | Electrophoretic mobility | cm2 · min−1 · V−1 |
μeo | Electroosmotic mobility | cm2 · min−1 · V−1 |
M | Molarity | mol /L−1 |
M | Molar mass | g/mol |
M | Molecular mass | u = Da |
Mr | Relative molar mass | — |
N | Number of theoretical plates | — |
ν | Frequency | Hz (s−1) |
pI | Isoelectric point | — |
P | Distribution ratio between 1‐octanol and aqueous solution, pH 7.4 | — |
P′ | Polarity index | — |
φ | Quantum yield (fluorescence) | — |
r | Radius | m (mm) |
Rf | Retention factor (TLC) | — |
RS | Resolution (chromatography) | — |
ρ | Density | g/cm3 |
σ | Standard deviation | — |
s | Standard deviation |
T | Temperature | K, C |
T | Transmittance | — |
tR | Retention time | min |
tM | Hold‐up time | min |
t′R | Adjusted retention time | min |
u | Linear velocity (flow rate) | cm/s |
v | Velocity | m/s |
V | Volume | L, 1 mL = 1 cm3 |
VM | Hold‐up volume (void volume) (LC); total permeation volume (SEC) | mL |
VO | Exclusion volume | mL |
VR | Retention volume | mL |
W | Peak width | min |
Wh | Peak width at half height | min |
Mean | — |
z | Charge | — |
Constants
Avogadro's number | N | 6.0221 × 1023 mol−1 |
Faraday's constant | F | 9.649 × 104 · C(oulomb) · mol−1 = 96.485 kJ · mol−1 |
Gas constant | R | 8.314 J · K−1 · mol−1 |
Speed of light in vacuum | c | 2.998 × 108 m/s |
Planck's... |
Erscheint lt. Verlag | 11.2.2019 |
---|---|
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Pflege |
Medizin / Pharmazie ► Pharmazie ► PTA / PKA | |
Naturwissenschaften ► Biologie | |
Naturwissenschaften ► Chemie ► Analytische Chemie | |
Schlagworte | Analytical Chemistry • Analytische Chemie • Biowissenschaften • Chemie • Chemistry • Forensic Science • Forensik • Life Sciences • Pharmaceutical & Medicinal Chemistry • Pharmazeutische Chemie • Pharmazeutische u. Medizinische Chemie |
ISBN-10 | 1-119-36275-X / 111936275X |
ISBN-13 | 978-1-119-36275-3 / 9781119362753 |
Haben Sie eine Frage zum Produkt? |
Größe: 23,9 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: EPUB (Electronic Publication)
EPUB ist ein offener Standard für eBooks und eignet sich besonders zur Darstellung von Belletristik und Sachbüchern. Der Fließtext wird dynamisch an die Display- und Schriftgröße angepasst. Auch für mobile Lesegeräte ist EPUB daher gut geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich