Growth Factors

1. Types of growth factor activity: detection and characterization of new growth factor activities ; 2. Detection of polypeptide growth factors: application of specific bio-assays and PCR technology ; 3. Induction of DNA synthesis and cell division in quiescent cells in response to small peptide growth factors ; 4. Novel gene transcription in response to growth factors: gene isolation by differential plaque hybridization ; 5. Embryological assays for growth factors ; 6. The role of TGF- in bone growth and bone repair ; 7. Localization of growth factor mRNA in tissue sections by in-situ hybridization ; 8. Detection and characterization of growth inhibitory factors: epidermal inhibitory pentapeptide (EIP) ; 9. Expression of growth factors in microbial systems ; 10. Immunoassays for growth factors ; 11. Determination of growth factor receptor distribution by immunocytochemistry or autoradiography and quantitation by ligand binding or FACS analysis ; Appendices