Biomarkers of the Tumor Microenvironment

Lars A. Akslen, M.D., Ph.D., Centre for Cancer Biomarkers, Department of Clinical Medicine, The Gade Laboratory for Pathology University of Bergen, NORWAY Randolph S. Watnick, Ph.D., Assistant Professor, Department of Surgery, Harvard Medical School, Vascular Biology Program, Boston Children's Hospital Boston, USA

Markers of tumor-vascular interactions.- Extracellular matrix, especially integrins, importance for tumor progression.- Role of Axl for epithelial-mesenchymal transition and tumor spread.- Models of tumour progression in prostate cancer.- Biomarkers of tumor progression in malignant melanoma.- Biomarker signatures and tumor progress in breast cancer.- Biomarker panels and contemporary practice in clinical trials of targeted treatment.- Role of prosaposin in niche regulation and metastatic spread.- Regulators of microenvironment and metastases in prostate cancer.- Semaphorins and angiogenesis.- Heterogeneity of angiogenesis phenotypes.- Biology of metastatic niches.- Lymphangiogenesis and tumor progress.- Extracellular matrix.- Paracrine signalling and tumor progress.- Cancer associated fibroblasts.- Tumor immunology.- Interleukins and inflammatory programs in tumor progress.- Global gene expression signatures of the tumor microenvironment.- Microarray analysis of the tumour microenvironment.- Studies of the tumor microenvironment.