Diffuse Low-Grade Gliomas in Adults

Hugues Duffau, after his residency and habilitation 2002 at the University Paris VI, became Professor 2006 and Head of the Department of Neurosurgery, Montpellier, France in 2007. He is one of the leading experts in low grade glioma surgery and well known for his holistic view of the brain and his pursuit for changing paradigms in neurooncological surgery. For him, a deep understanding of anatomy, functional imaging, intraoperative mapping and neuropsycological assessments is mandatory to open new doors to personalized therapeutic strategies for patients. With 227 publications and four books, he is in the editorial board of five journals and member of several neurosurgical and neuroncological societies.

Foreword.- Introduction: Diffuse Low Grade Gliomas (DLGG).- Epidemiology.- Molecular Epidemiology and DLGG.- New Pathological Classification.- Towards an Intermediate Grade in Glioma Classification.- Genetics of DLGG.- Molecular Classification.- Pathogenesis of DLGG.- Mechanisms of DLGG migration.- Genomics of DLGG.- DLGG-associated stem cells.- Molecular imaging    .- Clinical Presentation.- Epilepsy and DLGG.- Quality of Life in patients with DLGG.- Oncological and Metabolic MRI.- Positron Emission Tomography.- Dynamics of DLGG and Clinical Implications.- Natural History and Spontaneous Prognostic Factors.- Language, Cognitive and Emotional Evaluation.- Functional MRI in DLGG.- Diffusion Tensor Imaging in DLGG.- Magnetoencephalography and Functional Connectivity in DLGG.- Interactions between DLGG and Neuroplasticity.- Surgery: Oncological Considerations.- Surgery: Functional Considerations.- Chemotherapy^tion in Patients with DLGG.- New Individualized Strategies.- Pregnancy and DLGG.- Social cognition and DLGG.- Biomathematical Modeling of the DLGG Behavior.- Towards a Resection Probability Map.- The Onco-functional Balance in DLGG.- The Origins of DLGG.- DLGG and Cognitive Neurosciences.