Biomarkers for Alzheimer’s Disease Drug Development

Epidemiology of Dementia: The Burden on Society, the Challenges for Research.- Population-based Approaches to Alzheimer’s Disease Prevention.- Systems Biology Methods for Alzheimer’s Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials.- CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform.- CSF N-glycomics using MALDI MS Techniques in Alzheimer’s Disease.- MicroRNA Profiling of Alzheimer’s Disease Cerebrospinal Fluid.- Validation of a Chemiluminescence Immunoassay for Measuring  Amyloid-β in Human Blood Plasma.- Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer’s Disease Research.- Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases.- Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development.- Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies.- Hybrid PET-MRI in Alzheimer’s Disease Research.- Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers.- The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer’s Dementia.- Quantification of Tau Load in Alzheimer’s Disease Clinical Trials Using Positron Emission Tomography.- Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach.- Unbiased Lipidomics and Metabolomics of Human Brain Samples.- Neuropathological Assessment as an Endpoint in Clinical Trial Design.- Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer’s Disease Biomarker Discovery.- Telomere length shortening in Alzheimer’s disease – procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study.- Quantifying miRNA Deregulation in Alzheimer’s Disease.- Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET.- In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models.- Cognitive Assessment in Alzheimer’s Disease Clinical Trials.- Data Mining and Machine Learning Methods for Dementia Research.