Recurrent Implantation Failure

Efstratios M. Kolibianakis, MD, MSc, PhD Associate Professor, Obstetrics & Gynecology and Assisted Reproduction, Unit for Human Reproduction, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece Christos A. Venetis MD, MSc(Res), MSc(HCM), PhD, FRANZCOG, CSST ReproMed (EBCOG/ESHRE) Consultant Gynaecologist and Fertility Specialist and Senior Lecturer, Centre for Big Data Research in Health & School of Women's & Children's Health, UNSW Medicine, Sydney, Australia

What is recurrent implantation failure? The psychological consequences of recurrent implantation failure. The role of lifestyle factors in recurrent implantation failure. Endocrine causes of recurrent implantation failure. Congenital uterine anomalies and recurrent implantation failure. Immunological causes of recurrent implantation failure: Comprehensive insights into mechanisms and therapeutic approaches. Acquired uterine conditions, reproductive surgery, and recurrent implantation failure. Thrombophilia: Diagnosis and management in women with recurrent implantation failure. Andrological causes of recurrent implantation failure. Diagnostic evaluation of the couple with recurrent implantation failure. Optimizing embryo culture for recurrent implantation failure. Optimizing endometrial receptivity for patients with recurrent implantation failure: The role of progesterone on the day of triggering final oocyte maturation. The role of late follicular phase luteinizing hormone and estradiol on embryo implantation: Implications for recurrent implantation failure. Manipulating the endometrium: Can recurrent implantation failure be managed by inducing endometrial inflammation or by the use of novel research therapies? The embryo in recurrent implantation failure: Genetic selection and strategies for improving its implantation potential. Is oocyte donation efficient in patients with recurrent implantation failure? Sperm donation and recurrent implantation failure. Optimizing embryo transfer technique for recurrent implantation failure management. When should patients abandon treatment? Proposed management of patients with recurrent implantation failure and directions for future research.