Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
Springer Verlag, Singapore
978-981-13-6243-9 (ISBN)
Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology.
1. Microbial Fraction Library: A Screening Source for Drug Discovery.- 2. Efficient Total Synthesis of Ōmura Natural Products.- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol.- 4. Synthetic Approaches on the Pluramycin-class Antibiotics.- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II.- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis.- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications.- 8. Total Synthesis of Ingenol.- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids.- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid.- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds.- 12. Exploring bioactive marine natural products and identification of their molecular targets.- 13. Target protein chemical modification.- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes
Erscheinungsdatum | 25.06.2019 |
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Zusatzinfo | 127 Illustrations, color; 279 Illustrations, black and white; XXV, 355 p. 406 illus., 127 illus. in color. |
Verlagsort | Singapore |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Medizin / Pharmazie ► Pflege |
Medizin / Pharmazie ► Pharmazie ► PTA / PKA | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Chemie ► Organische Chemie | |
Schlagworte | Cutting-edge organic synthesis • Fatty acid metabolites related to inflammation • Finding pharmaceutically promising compounds • Organic synthesis for chemical biology • Super-carbon chain compounds |
ISBN-10 | 981-13-6243-2 / 9811362432 |
ISBN-13 | 978-981-13-6243-9 / 9789811362439 |
Zustand | Neuware |
Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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