Diagnosis of Cutaneous Lymphoid Infiltrates

Antonio Subtil, MD, MBABoard Certified, Dermatopathology and HematopathologyAssociate Professor, Dermatology and PathologyYale University School of MedicineNew Haven, CTUSA

Part I: The Basics.- Clinical Pathological Correlation.- Skin Biopsy Evaluation.- Lymphocyte Morphology.- Lymphoid Follicle Morphology and Components.- Reactive Versus Neoplastic Lymphoid Follicles.- Extrafollicular Localization of Germinal Center Cells.- Part II: Histomorphologic Differential Diagnosis (DDx).- DDx of Epidermotropism.- DDx of Ulceration.- DDx of Perifollicular Accentuation.- DDx of Eosinophil-Rich Infiltrate.- DDx of Lymphoid Follicle Formation.- DDx of Angiocentrism.- DDx of Pannicular-based Infiltrate.- DDx of Large Cell Infiltrate.- Part III: Special Techniques.- Basic Immunohistochemistry Panels.- CD8-Positive Cutaneous Infiltrates.- Differential Diagnoses of CD30 Expression.- Differential Diagnoses of CD56.- EBV-positive Cutaneous Infiltrates.- Differential Diagnoses of BCL2-positive follicles.- Part IV: Diagnostic Entities.- Secondary Cutaneous Invovlement by Systemic/Nodal Lymphomas.- Classic Mycosis Fungoides (MF).- Folliculotropic Mycosis Fungoides (FMF).- Pagetoid Reticulosis.- Granulomatous Slack Skin.- Sezary Syndrome.- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Primary Cutaneous Anaplastic Large Cell Lymphoma.- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Lymphomatoid Papulosis.- Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferate Disorder.- Subcutaneous Panniculitis-like T-cell Lymphoma (alpha-beta).- Cutaneous Gamma-Delta T-cell Lymphoma.- Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma.- Extranodal NK/T-cell Lymphoma, Nasal Type.- Hydroa Vacciniforme-like T-cell Lymphoproliferative Disorder.- Adult T-cell Leukemia/Lymphoma (ATLL).- Primary Cutaneous Acral CD8+ T-cell Lymphoma (Indolent DC8+ Lymphoid Proliferation of the Ear).- Primary Cutaneous Peripheral T-cell Lymphoma, Unspecified.- Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type.- Primary Cutaneous Diffuse Large B-cell Lymphoma, Other.- Primary Cutaneous Follicle Center Lymphoma.- Primary Cutaneous Marginal Zone B-cell Lymphoma.- Lymphomatoid Granulomatosis (LYG).- Blastic Plasmacytoid Dendritic Cell Neoplasm.- Appendices.