Blick ins Buch

Molecular Diagnostics in Cytopathology (eBook)

A Practical Handbook for the Practicing Pathologist

Sinchita Roy-Chowdhuri, Paul A. VanderLaan, John M. Stewart, Gilda da Cunha Santos (Herausgeber)

eBook Download: PDF

2018 | 1st ed. 2019
XV, 534 Seiten
Springer International Publishing (Verlag)
978-3-319-97397-5 (ISBN)

Lese- und Medienproben

Ebook-Leseprobe (PDF)

Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding.

The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information.

Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.

Sinchita Roy-Chowdhuri

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

Paul A. VanderLaan

Beth Israel Deaconess Medical Center

Harvard Medical School

Boston, MA

USA

John M. Stewart

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

Gilda da Cunha Santos

Sunnybrook Health Science Center

Toronto, Ontario

Canada

Sinchita Roy-ChowdhuriThe University of Texas MD Anderson Cancer CenterHouston, TXUSAPaul A. VanderLaan Beth Israel Deaconess Medical CenterHarvard Medical SchoolBoston, MAUSAJohn M. StewartThe University of Texas MD Anderson Cancer CenterHouston, TXUSAGilda da Cunha SantosSunnybrook Health Science CenterToronto, OntarioCanada

Introduction: Overview of Current Molecular Diagnostic Testing on Cytology Samples.- The Cytology Specimen and Preparations: Advantages and Limitations.- Sample Acquisition and Test Requisition.- Pre-Analytic Workflow and Specimen Evaluation.- DNA-Based Sequencing Assays.- RNA-Based Assays.- FISH Testing of Cytology Specimens: Pre-Analytic, Analytic and Post-Analytic Considerations.- Molecular Cytopathology Correlations: Interpretation of Molecular Diagnostic Results.- Human Papillomavirus (HPV) Testing of Head and Neck Cancers.- Human Papillomavirus (HPV) Testing on Cervical Cytology Specimens.- Molecular Diagnostics in Lung Cytology.- Molecular Diagnostics in Thyroid Cytology.- Molecular Diagnostics in Breast Cytology.- Molecular Diagnostics in Salivary Gland Cytology.- Molecular Diagnostics in Pancreatic and Biliary Cytology.- Fluorescence In Situ Hybridization (FISH) Testing in Urinary Tract Cytology.- Molecular Diagnostics in Hematological Malignancies.- Molecular Diagnostics in Bone and Soft Tissue Tumors.- Molecular Diagnostics in Pediatric Cytopathology.- Molecular Cytopathology: Final Thoughts and Future Directions.

Erscheint lt. Verlag	21.11.2018
Zusatzinfo	XV, 534 p. 93 illus., 91 illus. in color.
Verlagsort	Cham
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	cytology specimen • FISH assays • Human papillomavirus • Laboratory processing • RT-PCR assays • Solid organ malignancies
ISBN-10	3-319-97397-5 / 3319973975
ISBN-13	978-3-319-97397-5 / 9783319973975

Haben Sie eine Frage zum Produkt?

PDF (Wasserzeichen)
Größe: 10,8 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Print-Ausgabe

Buch | Softcover

128,39 €