Cadmium Toxicity

Overview. Overview of historical and current problems of cadmium pollution in Japan.- Health effects of cadmium in human populations and its relation to cadmium exposure levels. History and present status of Itai-Itai disease.- Pathophysiology of renal and bone lesions in Itai-itai disease.- A long-term follow-up study of the residents exposed to cadmium in Kakehashi River basin.- Effects of cadmium exposure on life prognosis.- Evaluation of cadmium exposure and health effects among rice farmers in Akita prefecture.- Cadmium intake from foods among general population in Japan and Asia.- Rice contamination by cadmium and its remediation. Regulation of cadmium contents in rice.- Molecular mechanism of cadmium accumulation in rice.- Mitigation technologies of cadmium and arsenic in rice.- Development of low-cadmium-accumulating rice.- New aspects in the mechanisms of cadmium toxicity. Novel mechanisms of cadmium-induced cell death.- Cadmium transport and toxicity in the kidney.- Disturbance in phosphorus metabolism by cadmium exposure.