Head and Neck Cancers (eBook)

Contents

Contributors

Preface

SECTION I

Epidemiology, Biology, Diagnosis, and Staging

1. Head and Neck Cancer Epidemiology

Angela L. Mazul, Erich M. Sturgis, Andrew F. Olshan, and Jose P. Zevallos

2. Pathology of HNSCC

Michelle D. Williams and Adel K. El-Naggar

3. The Genomic Landscape of HNSCC

Steffen Wagner, Jens P. Klussmann, and Ruud H. Brakenhoff

4. HPV-Related Head and Neck Cancer Biology

Farhoud Faraji and Carole Fakhry

5. Imaging of Head and Neck Cancers

Rathan M. Subramaniam

SECTION II

Established and Emerging Treatment Modalities

6. Advances in Radiation Therapy Techniques for HNSCC: Image-Guided RT Stereotactic, IMRT-VMAT, MRI-Linac and Simulation

Jussi Sillanpaa, C. Jillian Tsai, and Nancy Y. Lee

7. Proton Therapy

Pierre Blanchard, G. Brandon Gunn, and Steven J. Frank

8. Transoral Robotic Surgery: Advances and Applications

Meghan T. Turner, F. Christopher Holsinger, and Robert L. Ferris

9. Induction Chemotherapy: Current and Emerging Role in HNSCC

Glenn J. Hanna and Robert I. Haddad

10. Immunotherapy for HNSCC: Rationale and Clinical Applications

Jennifer Moy, Jennifer M. Johnson, Jessica Moskovitz, Robert L. Ferris, and Athanassios Argiris

11. Targeting the Human Epidermal Receptor Family in HNSCC

Emmanuel Seront, Sandra Schmitz, and Jean-Pascal Machiels

12. Therapies Targeting VEGF/Angiogenesis and Other Novel Targets and Therapies in HNSCC

Sophie Stock-Martineau, Yanqun Dong, Denis Soulières, and Thomas J. Galloway

SECTION III

Site-Specific Management

13. Oropharyngeal Cancer: HPV-Positive Disease

Christien A. Kluwe, Anthony J. Cmelak, and Barbara A. Burtness

14. Non–HPV-Associated Oropharyngeal Cancer

Meghan T. Turner, Anirudh Saraswathula, and F. Christopher Holsinger

15. Oral Cavity Cancer: Surgical Approaches and Postoperative Treatment

Antoine Eskander, Jacques Bernier, Lisa Licitra, Paolo Bossi, and Theodoros N. Teknos

16. Nasopharyngeal Cancer

Wai Tong Ng, Oscar S. H. Chan, Henry C. K. Sze, Ka On Lam, and Anne W. M. Lee

17. Hypopharyngeal Cancer: A Multidisciplinary Approach

Moran Amit, Loren K. Mell, Cristina P. Rodriguez, and Neil D. Gross

18. Laryngeal Cancer: Organ Preservation Strategies

Arlene A. Forastiere, Jae Lee, Steven B. Chinn, Karim Boudadi, Avraham Eisbruch, Randal S. Weber

19. Malignancies of the Paranasal Sinuses and Skull Base

Heather A. Osborn, Jong Chul Park, Nabil F. Saba, Pierre Blanchard, and Derrick T. Lin

20. Evaluation and Treatment of Metastatic Lymphadenopathy From an Unknown Primary

Shirin Attarian, Richard Blake Ross, Shlomo A. Koyfman, and Missak Haigentz, Jr.

21. Salivary Gland Malignancies

Cristina P. Rodriguez, Jessica L. Geiger, Jon Mallen-St. Clair, Patrick K. Ha, Sue S. Yom, Adam S. Garden, and David J. Adelstein

SECTION IV

Recurrent or Metastatic Disease

22. Locally Recurrent HNSCC: Salvage Surgery, Reirradiation

Antoine Eskander, Sharon A. Spencer, Corey J. Langer, Takashi Maruo, Ryuichi Hayashi, Sadamoto Zenda, and James W. Rocco

23. Recurrent or Metastatic HNSCC: Systemic Therapy

Tomohiro Enokida, Susumu Okano, and Makoto Tahara

SECTION V

Supportive Care and Special Patient Groups

24. Oral Complications

Rajesh V. Lalla and Douglas E. Peterson

25. Dysphagia in Patients With Head and Neck Cancer

Katherine A. Hutcheson and Jan S. Lewin

26. Quality of Life Assessment and Patient-Reported Outcomes in Head and Neck Cancer

Minh Tam Truong and Lisa Ann Kachnic

27. Management of Head and Neck Cancers in the Elderly

Jessica L. Geiger and Julie E. Bauman

Index