Genetics of Hematological Disorders

Part 1 Introduction: morbid anatomy of the human genome in relation to hematological disorders - role of gene mapping in hematology. Part 2 Thalassemias: cis- and trans-acting elements that participate in the development of the human B-globin gene locus; hemoglobinopathies and erythrocyte enzymopathies in the populations of the USSR. Part 3 Enzymopathies of the red cell: glucose 6-phosphate dehydrogenase deficiency - an update. Part 4 Hemophilia: carrier detection in hemophilia A. Part 5 Leukemias: balanced familial (2;8) translocation in a young girl with ph-positive chronic myelogenous leukemia; heterochromatin polymorphism in patients with malignant diseases; cytogenetic backup of diagnosing and monitoring leukemia. Part 6 Hematological manifestations: Bloom's syndrome - incidence, age of onset, and types of leukemia in the Bloom's syndrome registry; cytogenetics in the 21st century.