Genetic Factors in Drug Therapy

Preface; Part I. Introduction: 1. The arrangement of the information in this volume; 2. General introduction; 3. Classification of pharmacogenetic phenomena; Part II. Cytochrome P450 Based Phenomen: 4. Cytochrome P450 - general features; 5. Artlhydrocarbon hydroxylase (cytochrome P450 1A1 and 1A2); 6. The mephenytoin hydroxylation polymorphism (cytochrome P450 2C18); 7. The debrisoquine/sparteine polymorphism (cytochrome P450 2D6); 8. The cytochrome P450 3A subfamily; 9. Tolbutamide; 10. Phenytoin; 11. Some other drugs of special interest; 12. Cytochrome P450 reductase; 13. General conclusions; Part III. Cholinesterase: 14. Cholinesterase; Part IV. Alcohol and Alcoholism: 15. Alcohol and alcoholism; Part V. N-Acetyltransferase: 16. N-Acetyltransferase; Part VI. Miscellaneous Phase II Reactions Showing Genetic Variability in Drug Metabolism: 17. The glucosidation of amobarbital; 18. Glucuronosyltransferases; 19. Glutathione-S-transferase; 20. Methylation reactions; 21. Paraoxonase; 22. Sulphotransferases; 23. Sulphoxidation deficiency; 24. Halothane hepatitis and other topics; Part VII. Glucose-6-Phosphate Dehydrogenase Deficiency: 25. Glucose-6-phosphate dehydrogemase deficiency; Part VIII. The Hepatic Porphyrias: 26. The hepatic porphyrias; Part IX. Malignant Hyperthermia: 27. Malignant hyperthermia; Part X. Miscellaneous Systems Showing Genetic Variability in Response to Drugs; 28. Chlorpropamide-alcohol flushing; 29. Glucocorticosteroids and intraocular pressure; 30. Unstable haemoglobins; 31. Human lymphocyte antigens and adverse reactions to drugs; 32. The polymorphism for tasting phenylthiocarbamide (PTC syn phenylthiourea); 33. Hereditary anticoagulant resistance; 34. NADH-cytochrome b5 reductase; 35. Catalase; 36. Antibiotic-induced deafness, chloramphenicol toxicity and other topics; Part XI. Polygenic Effects in Pharmacogenetics: 37. Polygenic effects in pharmacogenetics; Part XII. Common Themes: 38. Common themes; Part XIII. Conclusions: 39. Conclusions; Part XIV. Appendices: Index.