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Cardiovascular Complications in Cancer Therapy (eBook)

Antonio Russo, Giuseppina Novo, Patrizio Lancellotti, Antonio Giordano, Fausto J. Pinto (Herausgeber)

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2018 | 1st ed. 2019
XIII, 224 Seiten
Springer International Publishing (Verlag)
978-3-319-93402-0 (ISBN)

Lese- und Medienproben

Ebook-Leseprobe (PDF)

This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage potentially induced by antineoplastic drugs.

Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated.

The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing, during his every day practice, cardiovascular toxicity in cancer and hematologic patients.

The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.

This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.

All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects. The authors will provide their manuscript according to current literature and clinical research studies.

The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.

Giuseppina Novo, MD, PhD
Associate Professor of Cardiology
Biomedic Department of Internal Medicine and Specialities (DIBIMIS) University of Palermo, Italy
Division of Cardiology, University Hospital P. Giaccone
Palermo, Italy

Patrizio Lancellotti, MD, PhD
University of Liège Hospital, GIGA Cardiovascular Sciences
Department of Cardiology
CHU Sart Tilman, Liège, Belgium
Gruppo Villa Maria Care and Research, Anthea Hospital
Bari, Italy

Antonio Giordano, MD PhD
Director, Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology
College of Science and Technology
Temple University
PA 19122
USA

Fausto J. Pinto, MD, PhD, FESC, FACC, FSCAI, FASE
Professor, University Hospital Santa Maria, CHLN
University of Lisbon, Portugal
Dept. of Cardiology
Av Prof Egas Moniz
Lisboa 1649-028 Portugal

Antonio Russo, MD, PhDFull Professor of Medical OncologyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.)University of Palermo, ItalyDirector of Medical Oncology Section, University Hospital P. GiacconePalermo, Italy Giuseppina Novo, MD, PhDAssociate Professor of CardiologyBiomedic Department of Internal Medicine and Specialities (DIBIMIS) University of Palermo, ItalyDivision of Cardiology, University Hospital P. GiacconePalermo, ItalyPatrizio Lancellotti, MD, PhDUniversity of Liège Hospital, GIGA Cardiovascular SciencesDepartment of CardiologyCHU Sart Tilman, Liège, BelgiumGruppo Villa Maria Care and Research, Anthea HospitalBari, ItalyAntonio Giordano, MD PhD Director, Sbarro Institute for Cancer Research and Molecular Medicine and Center of BiotechnologyCollege of Science and TechnologyTemple UniversityPA 19122USAFausto J. Pinto, MD, PhD, FESC, FACC, FSCAI, FASEProfessor, University Hospital Santa Maria, CHLNUniversity of Lisbon, PortugalDept. of CardiologyAv Prof Egas MonizLisboa 1649-028 Portugal

Introduction.- Mechanisms of Cardiovascular Damage Induced by Traditional Chemotherapy.- Molecular Mechanisms of Cardiovascular Damage Induced by Anti HER2 Therapies.- Cardiovascular Damage Induced by Radiotherapy.- Cardiovascular Damage Induced by Anti-VEGF Therapy.- Cardiovascular Damage Induced by Anti-BCR-ABL TKIs.- Heart Failure and Left Ventricular Dysfunction.- Coronary Artery Disease.- Peripheral Artery Disease and Stroke.- Valvular Heart Disease.- Arterial Hypertension.- Atrial Fibrillation in Cancer.- Management of QT Prolongation Induced by Anti-cancer Drugs.- Pulmonary Hypertension Induced by Anti-cancer Drugs.- Venous Thromboembolism.- Early Detection of Cardiac Damage.- Diagnosis of Cardiac Damage: Role of Stress Echo.- Early Detection and Monitoring of Vascular Damage.- Prevention and Clinical Management of Cardiovascular Damage Induced by Anticancer Drugs: Need for Early Biomarkers and Cardio- and Vasculo-Protection in Personalized Therapy.- Cardiovascular Damage in Clinical Trials.

Erscheint lt. Verlag	4.10.2018
Reihe/Serie	Current Clinical Pathology
Reihe/Serie	Current Clinical Pathology
Zusatzinfo	XIII, 224 p. 41 illus., 38 illus. in color.
Verlagsort	Cham
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	anti HER-2 inhibitors • anti-VEGF therapy • Peripheral Arterial Disease • Pulmonary hypertension • Venous Thromboembolism
ISBN-10	3-319-93402-3 / 3319934023
ISBN-13	978-3-319-93402-0 / 9783319934020

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