Gene Therapy for Diseases of the Lung

Kenneth Brigham (Edited by)

Overview

Human Gene Therapy: The Initial Concepts, W. French Anderson
Discovering Genes That Cause Disease, Francis S. Collins

Delivering Genes to Human Lungs

Adenoviral Vectors for Gene Therapy of Inherited and Acquired Disorders of the Lung, David T. Curiel and Robert I. Garver, Jr.
Adeno-Associated Virus-Based Delivery Systems, Pamela L. Zeitlin
Cellular Responses to Adenovirus Entry, Susanna Chiocca and Matthew Cotton
Catonic Lipid-Based Gene Delivery: An Update, Xiang Gao
Liposome/Viral Hybrid Gene Delivery Systems, Arlene A. Stecenko

Gene Therapy in the Lung: The Next Generation

Manipulating the Intracellular Trafficking of Nucleic Acids, Kathleen E. B. Meyer, Lisa S. Uyechi, and Francis C. Szoka, Jr.
Delivery of Genes Through the Lung Circulation, David M. Rodman and Elizabeth G. Nabel
Targeting Gene Expression to the Lung, Jeffrey A. Whitsett and Stephan W. Glasser
Strategies to Accomplish Targeted Gene Delivery Employing Tropism-Modified Adenoviral Vectors, Joanne T. Douglas and David T. Curiel

Disease-Directed Gene Therapy

Toward Correction of the Genetic Defect in Cystic Fibrosis, Larry G. Johnson and Richard C. Boucher
Correction of the Genetic Defect in Alpha-1 Antitrypsin Deficiency by Somatic Gene Therapy, Randy C. Eisensmith and Savio L. C. Woo
Gene Therapy for Chronic Inflammatory Diseases of the Lungs, Angelo E. Canonico
Gene Therapy for Acute Diseases of the Lungs, Kenneth L. Brigham
Gene Therapy for Lung Cancer, Choon-Taek Lee and David P. Carbone

Epilogue

The Regulatory Process and Gene Therapy, Suzanne Epstein
Some Issues Affecting Progress Toward Human Gene Therapy and Potential Application to the Lung, Theodore Friedmann