FSH: Action and Intraovarian Regulation

FSH structure and function: Converting heterodimeric gonadotropins to genetically linked single chains. Isoforms of circulating FSH. Interpretation of immuno- and bioassays of human FSH. Recombinant human FSH: future prospects for clinical use. FSH action and regulation: FSH - receptor interactions and signal transduction. Follicular development: impact on oocyte quality. The human ovarian insulin-like growth factor system. Comparison of the effects of inhibin-A and inhibin-B on androgen production by human thecal cells in vitro. Ovarian response following GnRH agonist suppression of endogenous gonadotropins. Age-dependent changes in serum FSH levels. Luteinizing hormone: Mutations and polymorphism in the gonadotropin genes. Vascular endothelial growth factor is an intraovarian regulator of angiogenesis and corpus luteum formation. Relevance of high and low LH for ovarian function. FSH clinical aspects: Sonographic assessment of human follicle development. Serum FSH and inductio n of ovulation. Serum FSH and ovarian hyperstimulation for IVF. FSH and ovarian function during combined oral contraceptive regimens. The human aromatase enzyme: from gene to clinic. Polycystic ovary syndrome and cardiovascular disease. Hormone regulation of apoptotic cell death during ovarian follicular atresia. Index.