Hepatobiliary Transport: From Bench to Bedside -

Hepatobiliary Transport: From Bench to Bedside

Buch | Hardcover
167 Seiten
2001
Springer (Verlag)
978-0-7923-8771-8 (ISBN)
160,49 inkl. MwSt
There has been a tremendous amount of scientific progress in our understanding of the molecular mechanisms of transport processes in the liver within the last few years. Cloning of various members of organic anion and cation transporters has provided the necessary tools to study their regulation under physiological and pathophysiological conditions and has advanced our knowledge about bile formation. Mutations of various hepatic organic anion transporters have been identified in humans as hereditary defects leading to the heterogenous syndrome of progressive familial intrahepatic cholestasis (PFIC). Various mouse models including knockout animals have given us the opportunity to gain insight into lipid transport by the liver and the genetics of cholesterol gallstone formation. The physiology of bile duct cells and the molecular mechanisms leading to various cholangiopathies have been a main scientific focus in hepatology in recent years. Drug targeting to the liver by hepatic organic anion transporters represents an attractive way of selective delivery of pharmaceutical agents in humans. Ursodeoxycholic acid is successfully used in the treatment of patients with chronic cholestatic liver disease and major advances have been made in understanding its mode of action in liver and bile duct cells.
This book, the proceedings of the Falk Workshop held in Aachen, Germany, on 25-26 January 2001, contains chapters on all important aspects of biliary transport by well-known experts in this field. It is an essential resource for new developments in the field of biliary transport, both in basic science and clinical medicine.
Erscheint lt. Verlag 31.12.2001
Reihe/Serie Falk Symposium ; 121A
Zusatzinfo XI, 167 p.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Chirurgie Viszeralchirurgie
Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizinische Fachgebiete Innere Medizin Hepatologie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
ISBN-10 0-7923-8771-6 / 0792387716
ISBN-13 978-0-7923-8771-8 / 9780792387718
Zustand Neuware
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von Harald Daum; Werner Sellmer; Anke Bültemann

Buch | Softcover (2023)
MWV Medizinisch Wissenschaftliche Verlagsgesellschaft
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