Clinical Aspects of Natural and Added Phosphorus in Foods

Orlando M. Gutiérrez, MD, MMSc Associate ProfessorDivision of Nephrology, Department of Medicine, School of MedicineDepartment of Epidemiology, School of Public HealthUniversity of Alabama at BirminghamBirmingham, AL   Kamyar Kalantar-Zadeh, MD, MPH, PHD, FAAP, FACP, FASN, FAHA, FNKFChief, Division of Nephrology & HypertensionProfessor of Medicine, Pediatrics and Public HealthUniversity of California Irvine, School of Medicine, Orange and Irvine, CAAdjunct Professor of EpidemiologyDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CAStaff Physician and Principal InvestigatorVeterans Affairs (VA) Long Beach Healthcare System‎, Long Beach, CA Rajnish Mehrotra MD, MSProfessor of MedicineSection Head, Division of NephrologyHarborview Medical CenterUniversity of WashingtonSeattle, WA

I. Basic Phosphorus Physiology.- 1. The Story of Phosphorus.- 2. Overview of Phosphorus Homeostasis.- 3. Hormonal Regulation of Phosphorus Homeostasis: Parathyroid Hormone, Fibroblast Growth Factor 23, and Klotho.- II. Phosphorus in food.- 4. Phosphorus in the Modern Food Supply: Underestimation of Exposure.- 5. Nutritional Aspects of Phosphorus Compounds in Foods.- 6. Phosphorus Additives in Food Processing.- 7. Effects of Natural and Added Phosphorus Compounds in Foods in Health and Disease.- 8. Phosphorus Utilization in Animal Agriculture.- 9. Technical Aspects about Measuring Phosphorus in Food.- III.  Phosphorous – Nutrient interactions.- 10. Interaction Between Calcium and Phosphorus and the Relationship to Bone Health.- 11. Phosphate Deficiency and the Phosphate Depletion Syndrome:  Pathophysiology, Diagnosis, and Treatment.- 12. Dietary Phytate and Interactions with Mineral Nutrients.- IV. Phosphorus and Disease.- 13. Phosphorus and Kidney Disease: Mechanisms for Perturbed Phosphorus Homeostasis in Chronic Kidney Disease.- 14. Hidden Forms of Phosphorus in the Diet: Impact in the General Population and in Individuals with Chronic Kidney Disease.- 15. Dietary Phosphorus and Bone Disease.- 16. Phosphorus and Cardiovascular Disease.- 17. Phosphorus and Malignancies.