Heart Failure

Johann Bauersachs, Javed Butler, Peter Sandner (Herausgeber)

Buch | Softcover

IX, 581 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-86673-4 (ISBN)

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This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies. The main focus of this book is to review current and emerging heart failure therapies and potential targets for treatment.

Introduction.- Epidemiology.- Clinical trial design, endpoints and regulatory requirements. Biomarkers HFpEF/HFrEF. Imaging Technologies / MRI and Echo. Comorbidities in HF. Current Guideline based therapy of HFreF and HFpEF. New and Emerging Therapies and Targets. Ivabradine.- Beta3 agonists.- Novel MRAs.- pGCs and Natriuretic peptides.- sGC stimulators.- PDE's.- Adenosin and A1 Agonists.- Myosin heavy chain / Troponin.- Stem cells.- Diuretics and Vasopressin.- GeneTherapy.- RNA-based therapies and micro RNAs.- Cardiac myosin activation using gene therapy.- Bendavia - mitochondrial therapies.- WNT signaling.- Anticoagulation therapy and NOACS in HF.- Potassium Binders.- Iron.

Erscheinungsdatum	05.03.2022
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	IX, 581 p. 100 illus., 30 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	8832 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Schlagworte	Biomarkers • Clinical Trials • epidemiology • Heart Failure • Preserved ejection fraction • Reduced ejection fraction
ISBN-10	3-319-86673-7 / 3319866737
ISBN-13	978-3-319-86673-4 / 9783319866734
Zustand	Neuware