Imaging Biomarkers

Luis Martí-Bonmatí, MD, PhD Luis Martí-Bonmatí is radiologist and Chairman of the Clinical Area of Medical Imaging at La Fe Polytechnics and University Hospital in Valencia, Spain. He has been a member of the Executive Council and has served as Director of the Research Committee of the European Society of Radiology (ESR) from 2010 to 2013, starting the Imaging Biomarkers Subcommittee. He is currently a member of the European Imaging Biomarkers Alliance (EIBALL) and of the Scientific Council of the European Institute of Biomedical Imaging Research (EIBIR). Martí-Bonmatí is author of a high number of publications focused on Magnetic Resonance, Clinical Radiology, the development of Imaging Biomarkers, and Engineering-supported Biomedical Research. He is currently Associate Editor of European Radiology and Radiology journals. Angel Alberich-Bayarri, PhD Angel Alberich-Bayarri is biomedical engineer and Scientific-Technical Director at the Biomedical Imaging Research Group (GIBI230) at La Fe Polytechnics University Hospital. He has worked in the development of several algorithms for Imaging Biomarkers analysis that promoted the creation of the start-up QUIBIM (Quantitative Imaging Biomarkers in Medicine), focused in the creation of a platform for the analysis of Imaging Biomarkers. He is member of the board of the European Society of Medical Imaging Informatics (EUSOMII) and of the e-Health and Informatics Subcommittee of the European Society of Radiology (ESR). Alberich-Bayarri is authors of several publications in the field of imaging biomarkers. He received the MIT Innovators Under 35 award in 2015.

The shift in paradigm to precision medicine in imaging.- International initiatives for the promotion of imaging biomarkers.- Introduction to the stepwise development of imaging biomarkers.- Defining the biological basis and clinical question: proof of concept.- Looking for the inter-relationship: proof of mechanism.- Images acquisition: modality and protocol definition.- Images preparation.- Imaging biomarkers analysis.- Imaging biomarkers measurements.- Detecting measurement biases: the proof of principle.- Validating the imaging biomarker: the proof of efficacy and effectiveness.- The final step: Reporting imaging biomarkers results.- Sources of uncertainty: accuracy and precision of the measurements.- Pearls and pitfalls in Gold standards and biological correlation.- Imaging biobanks, big data and population-based imaging biomarkers.- A proposed Imaging Biomarkers analysis platform architecture for integration in clinics.- Use case I: Imaging biomarkers in neurodegenerative disease.- Use case II: Imaging biomarkers in tumors.- Use case III: Imaging biomarkers in thorax and heart.- Use case IV: Imaging biomarkers in musculoskeletal disorders.- Use case V: Imaging biomarkers in diffuse liver disease.

"This book discusses all the aspects of establishing an imaging biomarker by systemically guiding the reader through the various steps of development. ... a book that will provide an excellent induction for novices in this field. For someone contemplating developing a new biomarker to measure a disease process of interest, or for industry employees entering the world of monitoring new treatments using biomarkers, this book will be an excellent reading and stimulate further thinking." (Professor Frederik Barkhof, RAD Magazine, December, 2017)

“This book discusses all the aspects of establishing an imaging biomarker by systemically guiding the reader through the various steps of development.  …  a book that will provide an excellent induction for novices in this field. For someone contemplating developing a new biomarker to measure a disease process of interest, or for industry employees entering the world of monitoring new treatments using biomarkers, this book will be an excellent reading and stimulate further thinking.” (Professor Frederik Barkhof, RAD Magazine, December, 2017)