Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins -

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Ulf Grawunder, Stefan Barth (Herausgeber)

Buch | Softcover
XI, 181 Seiten
2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-83609-6 (ISBN)
160,49 inkl. MwSt

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

lt;br />

Chemical Assembly of Antibody-Drug Conjugates.- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers.- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents.- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications.- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates.- Substance P - Saporin for the Treatment of Intractable Pain.- Recombinant immunotoxins for Chronic Inflammatory Disease.- BL22: A milestone in targeting CD22.






Erscheinungsdatum
Reihe/Serie Milestones in Drug Therapy
Zusatzinfo XI, 181 p. 57 illus., 39 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 308 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium Querschnittsbereiche Infektiologie / Immunologie
Schlagworte antibodies • Antibody based cancer therapy • Antibody drug conjugates (ADC) • Calicheamicin • Immunotoxin development • pharmacotherapy • Pyrrolobenzodiazepines • Substance P-Saporin • Substance P–Saporin
ISBN-10 3-319-83609-9 / 3319836099
ISBN-13 978-3-319-83609-6 / 9783319836096
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich

von Oliver Schmetzer

Buch | Softcover (2023)
Urban & Fischer in Elsevier (Verlag)
27,00