Free Fatty Acid Receptors

Graeme Milligan, Ikuo Kimura (Herausgeber)

Buch | Softcover

VIII, 256 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-84464-0 (ISBN)

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This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Ligands at Free Fatty Acid Receptor 1 (GPR40).- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41.- Ligands at GPR84.- Ligands at Free Fatty Acid Receptor 4 (GPR120).- Homology modelling of FFA receptors.- Sensors for FFA receptors.- Key questions for translation of FFA receptors from pharmacology to medicines.- Polymorphic variation in FFA receptors. Functions and consequences.- The role and future of FFA1 as a therapeutic target.- Gut hormone regulation and secretion via FFA1 and FFA4.- The role of FFA2 and FFA3 in metabolic regulation.- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors.- Free Fatty Acid receptors and cancer.

Erscheint lt. Verlag	13.7.2018
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	VIII, 256 p. 70 illus.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	551 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Diabetes • Homology modelling • inflammation • Ligand function • Receptors for Free Fatty Acids • systems biology
ISBN-10	3-319-84464-4 / 3319844644
ISBN-13	978-3-319-84464-0 / 9783319844640
Zustand	Neuware