Epilepsy

Gregory Cascino is a Professor of Neurology and principal investigator at the Mayo Clinic, in the National Institutes of Health funded study Epilepsy Phenome Genome Project (EPGP). He is interested in the care and management of patients with seizures and epilepsy and the evaluation of patients for surgical treatment of epilepsy.

Joseph Sirven is the Associate Professor of Neurology at the Mayo Clinic. His main interests are in Epilepsy and Seizure Treatments in Adults and Children (particularly older adults), Epilepsy Surgery, Electroencephalography, Investigational Antiepilepsy Drugs, Status Epilepticus, Vagal Nerve Stimulator, Ketogenic Diet. William Tatum, is a Neurologist at the Mayo Clinic, Jacksonville, FL, USA.

William O. Tatum is Professor of Neurology at the Mayo Clinic, Jacksonville, FL, USA.

Preface xxiii

Foreword xxv

List of Contributors xxvii

Section I Epilepsy: Epidemiology, Diagnostic Evaluation and Co-Morbidities 1

1 Introduction and Epidemiology 3
Joseph I. Sirven and Gregory D. Cascino

2 Classification of Seizures and the Epilepsies 11
Elaine C. Wirrell

3 Etiology and Pathology of Epilepsy 23
Katherine C. Nickels and Katherine Noe

4 Genetics of Epilepsy 37
Anthony L. Fine, Lily C. Wong-Kisiel and Raj D. Sheth

5 Burden of Epilepsy 63
J. Layne Moore, Amy Z. Crepeau and Gregory D. Cascino

6 EEG and Epilepsy 77
Anteneh M. Feyissa, Gregory A. Worrell and Terrence D. Lagerlund

7 Neuroimaging in Epilepsy 99
Benjamin H. Brinkmann, Elson L. So, Robert E. Watson and Amy L. Kotsenas

8 The Evaluation of Nonepileptic Paroxysmal Events 117
Sara Dawit and Joseph F. Drazkowski

9 Sleep, Sleep Disorders, and Epilepsy 133
Diego Z. Carvalho, J. Layne Moore and Erik K. St. Louis

Epilepsy Journey: Identification of a Genetic Etiology for Epilepsy 147
Anthony L. Fine, Lily C. Wong-Kisiel and Raj D. Sheth

Epilepsy Journey 2: Evaluation of Spells in Adults 153
David B. Burkholder

Epilepsy Journey 3: The Pediatric Patient with Spells: Recommendations for Evaluation 157
Katherine C. Nickels and Elaine C. Wirrell

Epilepsy Journey 4: Transitioning from Pediatric to Adult Epilepsy Clinic 165
Gregory D. Cascino, Katherine C. Nickels and Elaine C. Wirrell

Section II Epilepsy: Treatment of Epilepsy: Non-Surgical Therapy 169

10 First Seizure 171
Scott Spritzer and Omar Danoun

11 Antiseizure Medication Therapy 179
Kiran M. Kanth, Sarah Clark and Jeffrey W. Britton

12 Epilepsy in Women 217
Katherine Noe

13 Treating Children with Epilepsy: Antiepileptic Medications (AEDs) 229
Raj D. Sheth

14 Dietary Therapy in Epilepsy 239
Katherine C. Nickels and Elaine C. Wirrell

15 Autoimmune Epilepsy Disorders 249
Jeffrey W. Britton, Eoin P. Flanagan, Andrew McKeon and Sean J. Pittock

16 Discontinuation of Antiseizure Medication 275
Jamal F. Khattak and Jeffrey W. Britton

17 Investigational Therapy and Drug Approval Process within the US and Cannabidiol 287
Gregory Sprout, Joseph I. Sirven and Gregory D. Cascino

18 Devices to Monitor and Track Your Epilepsy 301
Nicholas M. Gregg and Amy Z. Crepeau

Epilepsy Journey 5: Seizure Emergencies (Include status Epilepticus, Fires, Norse, Seizure First Aid, and Seizure Clusters) 313
Anteneh M. Feyissa, Matthew T. Hoerth and Eric T. Payne

Epilepsy Journey 6: The First seizure -- How to Evaluate: Pediatric 315
Korwyn Williams

Epilepsy Journey 7: The First Seizure -- How to Evaluate: Adult 317
Paul M. Magtibay and Joseph I. Sirven

Epilepsy Journey 8: Treating Epilepsy Second Seizure and beyond: How to Choose a Drug -- An Algorithm 321
Amy Z. Crepeau

Epilepsy Journey 9: Treating Status Epilepticus: An Algorithm 325
Sara E. Hocker and Eric T. Payne

Epilepsy Journey 10: Withdrawal of ASDs in Adults: An Algorithm 331
Sarah A. Merrill, Kent R. Richter and Joseph I. Sirven

Epilepsy Journey 11: Withdrawal of ASDs in Seizure-Free Patients Children: The Pediatric
Neurologist’s Perspective 335
Elaine C. Wirrell

Epilepsy Journey 12: Withdrawing ASDs in Adults after Epilepsy Surgery 339
Christian Rosenow, Luca Farrugia, Andrew Pines and Joseph I. Sirven

Epilepsy Journey 13: The Pregnant Patient with Epilepsy: An Algorithm 343
Katherine Noe

Section III Epilepsy: Treatment of Epilepsy: Surgical Management 345

19 Pre-surgical Evaluation 347
David B. Burkholder, Anthony L. Ritaccio and Cheolsu Shin

20 Minimally Invasive Epilepsy Surgery 367
Sanjeet S. Grewal, Robert E. Wharen Jr. and William O. Tatum

21 Intracranial EEG Monitoring 381
Jamie J. Van Gompel, Katherine Noe and Richard S. Zimmerman

22 Surgical Strategies (Include Cortical Resection, Lesionectomy, Cortical Stimulation and Functional Mapping, Hemispherotomy) 401
Angela Bohnen, W. Richard Marsh, Alfredo Quinones-Hinojosa and Kaisorn L. Chaichana

23 Corpus Callosotomy 413
Elaine C. Wirrell, Lily C. Wong-Kisiel and Kai J. Miller

24 Neuromodulation for Epilepsy 431
Brian N. Lundstrom, Robert E. Wharen, Jr and William O. Tatum

25 Emerging Treatments for Epilepsy 441
Gregory A. Worrell, Benjamin H. Brinkmann, Brian N. Lundstrom and Matt Stead

26 Seizure Forecasting in Epilepsy: From Computation to Clinical Practice 451
Benjamin H. Brinkmann, Nicholas M. Gregg and Gregory A. Worrell

Epilepsy Journey 14: The Drug-Resistant Patient: Pre-surgical Evaluation and Surgery-Approach to the "Skip" Candidate 463
Anteneh M. Feyissa and David B. Burkholder

Epilepsy Journey 15: The Drug-Resistant Patient and Discordant Pre-surgical Evaluation 469
Lily C. Wong-Kisiel, Elson L. So and Richard S. Zimmerman

Epilepsy Journey 16: The Drug-Resistant Patient who is not a Candidate for Resective Surgery: An Approach to Neuromodulation 477
Anthony L. Ritaccio and William O. Tatum

Epilepsy Journey 17: Epilepsy Surgery in Pediatric Patients 483
Raj D. Sheth, Kai J. Miller and Elaine C. Wirrell

References 489

Index 491