Liquid Biopsies in Solid Tumors

Massimo Crisofanilli, MD, F.A.C.P, is Professor of Medical Oncology, Department of Medical Oncology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA.

1.Blood-based diagnostics in solid tumors: an overview.- 2.Circulating tumor cells (CTCs) in primary disease: the seed for metastasis.- 3.Enumeration and molecular analysis of CTCs in metastatic disease: The breast cancer model.- 4.Epithelial-Mesenchymal Transition (EMT) and cancer stem cells (CSCs): The traveling metastasis.- 5.Detection and monitoring of circulating immune cells in solid tumors: shifting priorities.- 6.Circulating-free tumor DNA (ctDNA): the real-time liquid biopsy.- 7.CTCs and ctDNA: two tales of a complex biology.- 8.Exosome: decoding the messaging system.

"The book 'Liquid biopsies in solid tumours' provides an overview of currently available technological approaches and clinical applications of liquid biopsies that offer an attractive alternative to invasive tumour biopsies. ... This book collects contribution from experts in the field of blood-based diagnostics. They help us to understand the future of early cancer detection, characterization and monitoring via liquid biopsies strategies, providing clinicians with the advantage to understand, predict and intervene." ( Bozena Smolkova, Neoplasma, Vol. 65 (1), January, 2018)