Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models - Aslak Tveito, Glenn T. Lines

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Buch | Softcover
XVI, 261 Seiten
2018 | 1. Softcover reprint of the original 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-80708-9 (ISBN)
53,49 inkl. MwSt

Flow of ions through voltage gatedchannels can be represented theoretically using stochastic differentialequations where the gating mechanism is represented by a Markov model. The flow through achannel can be manipulated using various drugs, and the effect of a given drugcan be reflected bychanging the Markov model. These lecture notes provide an accessibleintroduction to the mathematical methods needed to deal with these models. They emphasize the use ofnumerical methods and provide sufficient details for the reader to implementthe models and thereby study the effect of various drugs.  Examples in thetext include stochastic calcium release from internal storage systems in cells,as well as stochasticmodels of the transmembrane potential. Well known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model.

Preface.- Background: Contents and Method.- One-dimensional calcium release.- Models of open and state blockers.- Two-dimensional calcium release.- Computing theoretical drugs in the two-dimensional case.- Generalized systems.- Calcium-induced calcium release.- Numerical release for CICR.- A prototypical model of an ion channel.- Inactivated ion channels.- A simple model of the sodium channel.- Mutations affecting the mean open time.- The burst mode.- Whole sale action potentials.-  

Erscheinungsdatum
Reihe/Serie Lecture Notes in Computational Science and Engineering
Zusatzinfo XVI, 261 p. 129 illus., 30 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 4394 g
Themenwelt Informatik Grafik / Design Digitale Bildverarbeitung
Informatik Theorie / Studium Künstliche Intelligenz / Robotik
Mathematik / Informatik Mathematik Analysis
Mathematik / Informatik Mathematik Angewandte Mathematik
Medizin / Pharmazie
Schlagworte Differential Equations • drug modelling • ion channels • probability density functions • stochastic models
ISBN-10 3-319-80708-0 / 3319807080
ISBN-13 978-3-319-80708-9 / 9783319807089
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich
alles zum Drucken, Scannen, Modellieren

von Werner Sommer; Andreas Schlenker

Buch | Softcover (2024)
Markt + Technik Verlag
24,95
Einstieg und Praxis

von Werner Sommer; Andreas Schlenker

Buch | Softcover (2023)
Markt + Technik (Verlag)
19,95