Oxford Case Histories in Lung Cancer

Dr Himender Makker is a Consultant Respiratory Physician and Clinical Lead for Lung Cancer Service at the North Middlesex University Hospital. He established and developed Lung Cancer MDT team and service. He is a member of North and East London Lung Cancer Network, and contributes to the National Lung Cancer Audit and supports UCL and National Lung Cancer trials and projects. His research interests include sleep disordered breathing and asthma. Dr Adam Ainley is a Speciality Trainee Registrar in Respiratory Medicine and General (Internal) Medicine within the North East Thames rotation in London. He undertook postgraduate general medical training in Oxford and London prior to his higher specialist training, and is currently undertaking a PhD within the National Heart and Lung Institute at Imperial College London. Dr Sanjay Popat is a Consultant Thoracic Medical Oncologist at The Royal Marsden and Honorary Clinical Senior Lecturer in the Molecular Genetics and Genomics Group at the National Heart and Lung Institute, Imperial College London. He is Chair of the British Thoracic Oncology Group (BTOG). He is a specialist thoracic oncologist, and internationally recognised as an expert in the treatment of lung cancer, mesothelioma, and cancers of the thymus. His research interests include identification and validation of DNA variants that influence thoracic tumour development, identification of biomarkers, and the development of novel therapeutic strategies for thoracic tumours. Dr Julian Singer is a Consultant Oncologist specialising in lung cancer radiotherapy and chemotherapy at the North Middlesex University and Princess Alexandra Hospitals. He is a member of the Royal College of Physicians, the Royal College of Radiologists, and European Society of Medical Oncology. He is joint lead for lung cancer at Princess Alexandra Hospital, radiotherapy Lead for lung cancer at London Cancer Network, Oncology lead for breast cancer at Princess Alexandra Hospital and radiotherapy lung cancer lead at North Middlesex Hospital. Mr Martin Hayward is Consultant Thoracic Surgeon and Clinical Lead for Thoracic Surgery at University College Hospital, London. His research interests include heart failure, lung cancer surgery, and minimally invasive chest surgery. Dr Antke Hagena trained and graduated in Germany, and completed an MD in Public Health before starting a training post in Medicine. Her interest in Palliative Medicine, which is not a medical speciality in Germany, brought her to London in 1999. She now works at North Middlesex University Hospital and Marie Curie Hospice Hampstead. Before taking up her consultant post, she returned to Germany to set up a new palliative care unit and community team. Her main interests lie in service development, improving access, and equity of care for patients requiring palliative care support.

Epidemiology, presentation, diagnosis, and staging
1: Adam Ainley, Rebecca Gillibrand, and Himender Makker: Lung cancer in a 53 year old smoker
2: Adam Ainley and Himender Makker: Lung cancer in an ex-smoker with underlying lung fibrosis
3: Adam Ainley, Sashin Kaneria, and Himender Makker: Incidental solitary pulmonary nodule in an ex-smoker Afro-Caribbean lady
4: Adam Ainley and Himender Makker: Advanced lung cancer on CTPA in a patient presenting to Accident & Emergency department with chest pain and breathlessness
5: Adam Ainley and Himender Makker: Impaired vision in an ex-smoker
6: Adam Ainley and Himender Makker: Late recurrence or second primary lung cancer
7: Adam Ainley, Bryan Sheinman, and Himender Makker: Endobronchial tumour in a smoker with history of lymphoma
8: Adam Ainley and Himender Makker: Progressive breathlessness associated with a right sided pleural effusion
9: Adam Ainley, Sashin Kaneria, and Himender Makker: PET positive right lower lobe mass
10: Adam Ainley, Rebecca Gillibrand, and Himender Makker: Histology of right hilar mass in an ex-smoker
11: Adam Ainley, Rebecca Gillibrand, and Himender Makker: Pericardial and pleural effusions in a smoker with metastatic adenocarcinoma
12: Adam Ainley, Bryan Sheinman, and Himender Makker: Right lower lobe squamous cell carcinoma associated with hilar and mediastinal lymphadenopathy
13: Adam Ainley and Himender Makker: A 30 year old lady with solitary lesion and haemoptysis
14: Adam Ainley and Himender Makker: Asymptomatic metastatic disease in a 71 year man with history of frequent falls
Medical Oncology
15: Oscar Juan and Sanjay Popat: Metastatic small cell cancer presenting with haemoptysis and left upper lobe collapse, treated with chemotherapy
16: Oscar Juan and Sanjay Popat: Adenocarcinoma identified to be EGFR mutation positive
17: Oscar Juan and Sanjay Popat: Adenocarcinoma identified to be ALK fusion positive
18: Nadza Tokaca and Sanjay Popat: Relapsed stage 4 adenocarcinoma with insufficient material for genotyping at diagnosis
19: Spyros Gennatas and Sanjay Popat: Squamous cell carcinoma (SCC) of the lung in a patient with previous breast cancer
20: Adam Januszewski and Sanjay Popat: Non-resolving bilateral consolidation diagnosed as invasive mucinous adenocarcinoma with lepidic predominant pattern (previously known as bronchoalveolar carcinoma) on biopsy
21: Adam Januszewski and Sanjay Popat: Stage IIA adenocarcinoma of lung in a never smoker undergoing adjuvant chemotherapy
22: Spyros Gennatas and Sanjay Popat: Malignant pleural mesothelioma (MPM)
23: Spyros Gennatas and Sanjay Popat: Lung carcinoid tumour
24: Adam Januszewski and Sanjay Popat: A 54 year old with T4N2M0 squamous cell carcinoma who developed neutropenic sepsis on second course of chemotherapy
25: Adam Januszewski and Sanjay Popat: A 76 year old with oligometastatic stage IV squamous cell carcinoma who developed diarrhea on treatment with immune checkpoint inhibitors
26: Adam Januszewski and Sanjay Popat: A 55-year-old patient with relapsed stage IV ALK fusion positive adenocarcinoma treated with crizotinib, presenting with headaches
Clinical Oncology
27: Kobika Sritharan and Julian Singer: Drop Metastasis
28: Kobika Sritharan and Julian Singer: Superior vena cava obstruction (SVCO) due to lung cancer
29: Kobika Sritharan and Julian Singer: Pancoast tumour
30: Kobika Sritharan and Julian Singer: High dose palliative radiotherapy
31: Kobika Sritharan and Julian Singer: Stereotactic radiotherapy
Thoracic Surgery
32: Martin Hayward and Sofoklis Mitsos: A patient with T2N1M0 squamous cell carcinoma
33: Martin Hayward and Sofoklis Mitsos: Long term complications of thoracotomy- chest wall paraesthesia and neuralgic chest pain
34: Martin Hayward and Nikolaos Panagiotopoulos: Left pneumonectomy in a 25 year old with carcinoid tumour
35: Martin Hayward and Davide Patrini: Postoperative care of 60 year old man with Squamous cell carcinoma but with severe COPD and no other co-morbidities
36: Martin Hayward and Davide Patrini: Preoperative assessment and fitness for surgery- T2N0 M0 Left hilar squamous cell carcinoma in lady with severe COPD
Palliative care
37: Antke Hagena: An 84 year old lady with advanced staged disease, dementia and multiple co-morbidities
38: Antke Hagena: Use of nerve block in case of Right Lung Adenocarcinoma, received local radiotherapy and nerve block
39: Antke Hagena: Patient presenting with cough, breathlessness and haemoptysis, previously resected T1N0MO right upper lobe cancer
40: Antke Hagena: Case of Ex-Builder with pleural effusions secondary to mesothelioma